Human skin undergoes some morphological changes with the effects of chronological aging and photoaging, these are especially remarkable in the facial skin. Changes in pigmentation, sallowness, deep wrinkling, laxity and elastosis are the main changes seen in photoaging and chronologic aging of skin. With the increasing demand, it needs to provide new approach for the prevention and treatment of these morphological changes.

Fibroblasts have a key role on skin aging. It is known that platelet rich plasma activates the fibroblasts and increases the synthesis of collagen and other type of matrix components. Because of these specialities, platelet rich plasma is thought to be effective on skin aging.

Clinical evaluation of the patients will be done for five times during 3 months. 0th day (Basal), 7th day, 15th day, 45th day and 105th day.

Inclusion Criteria:

• The patient has periorbital wrinkles with Glogau Scale 3 or more

Exclusion Criteria:

• Patients with precancerous lesions
• Patients with inflammatory skin disease like rosacea, psoriasis, seborrheic eczema
• Patients with connective tissue disease like lupus erythematosus
• Patients have a cosmetic intervention to their face, like chemical peel, infrared, radio frequency, laser, fillers or botulinum toxin injections in last 6 months
• Patients who use an anti aging cream containing retinoic acid, vitamin C and peptides in last 3 months
• Pregnant or lactating females