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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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In animals, treatment with vitamin B3 improved insulin sensitivity and substrate metabolism. It is currently not know if vitamin B3 has the same positive effects in humans. In the current study the effect of a 3 month treatment with vitamin B3 on insulin sensitivity and substrate metabolism in obese men will be investigated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | lime tablets |
|
| Nicotinamide riboside (NR, Vit B3) | Experimental | NIAGEN (ChromaDex) 1 g x 2 orally per day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nicotinamide riboside (NIAGEN TM, ChromaDex, CA, USA ) | Dietary Supplement |
| ||
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin sensitivity | determined by a hyperinsulineamic clamp | Change from baseline in insulin sensitivity at 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Substrate metabolism | measured by indirect calorimetry | Change from baseline in substrate metabolism at 3 months |
| body composition | measured by DEXA scan |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ole Dollerup, MD | The Novo Nordisk Foundation Center for Basic Metabolic Research, Integrative Physiology, University of Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Research Laboratories, Aarhus University Hospital | Aarhus | 8000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31710095 | Derived | Dollerup OL, Chubanava S, Agerholm M, Sondergard SD, Altintas A, Moller AB, Hoyer KF, Ringgaard S, Stodkilde-Jorgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT. Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men. J Physiol. 2020 Feb;598(4):731-754. doi: 10.1113/JP278752. Epub 2019 Dec 26. | |
| 31390002 |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| C018613 | nicotinamide-beta-riboside |
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| Dietary Supplement |
|
| Change from baseline in body composition at 3 months |
| Activation of satellite cells | measured by immunohistochemestry | Change from baseline in activation of satellite cells at 3 months |
| lipid accumulation in liver and skeletal muscle tissue | determined by MR-spectroscopy | Change from baseline in liver and muscle lipid content at 3 months |
| glucose turnover | determined by glucose tracer techniques | Change from baseline in glucose turnover at 3 months |
| insulin signalling in skeletal muscle and adipose tissue biopsies | western blotting | Change from baseline in insulin signaling at 3 months |
| Palmitate turnover | determined by palmitate tracer techniques | Change from baseline in palmitate turnover at 3 months |
| Gut microbiota | Intestinal bacteria composition by whole genome sequencing | Change from baseline in composition of gut microbiota at 3 months |
| Incretin hormone secretion | Determined by measurement of incretin homones during an oral glucose tolerance test (OGTT) | Change from baseline in incretion hormone secretion at 3 months |
| Derived |
| Dollerup OL, Trammell SAJ, Hartmann B, Holst JJ, Christensen B, Moller N, Gillum MP, Treebak JT, Jessen N. Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity. J Clin Endocrinol Metab. 2019 Nov 1;104(11):5703-5714. doi: 10.1210/jc.2019-01081. |
| 29992272 | Derived | Dollerup OL, Christensen B, Svart M, Schmidt MS, Sulek K, Ringgaard S, Stodkilde-Jorgensen H, Moller N, Brenner C, Treebak JT, Jessen N. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr. 2018 Aug 1;108(2):343-353. doi: 10.1093/ajcn/nqy132. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |