Suprachoroidal Injection of Triamcinolone Acetonide With IVT Aflibercept in Subjects With Macular Edema Following RVO

TANZANITE: Safety and Efficacy of Suprachoroidal CLS-TA in Combination With Intravitreal Aflibercept in Subjects With Macular Edema Following Retinal Vein Occlusion

A phase 2, multicenter, randomized, active-controlled, masked, parallel arm study designed to evaluate the safety and efficacy of a single suprachoroidal injection of CLS-TA, triamcinolone acetonide injectable suspension, given along with an intravitreal (IVT) injection of aflibercept compared to IVT aflibercept alone in subjects with retinal vein occlusion (RVO).

A randomized, masked, controlled trial of safety and efficacy of suprachoroidal CLS-TA in combination with intravitreal aflibercept in subjects with macular edema following retinal vein occlusion

Inclusion Criteria:

• diagnosis of macular edema following RVO
• History of ME ≤ 12 months
• 20-70 letters inclusive BCVA using ETDRS

Exclusion Criteria:

• has had an IVT injection of anti-VEGF for RVO in the study eye
• has had a corticosteroid injection in the past 3 months in the study eye
• any uncontrolled ophthalmic condition in the study eye other than RVO