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The purpose of this study is to determine whether the acetate, butyrate and propionate concentration in breast milk and to evaluate the possible correlation of these concentrations with maternal diet.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sampling of breast milk, obtaining information about the maternal diet | Other | take samples of 3 ml breast milk and 3-days diet diaries |
| Measure | Description | Time Frame |
|---|---|---|
| butyrate, acetate and propionate concentration | 10 days after delivery and every 30 days until the fifth month after delivery |
| Measure | Description | Time Frame |
|---|---|---|
| Relationship between short chain fatty acids in breast milk and maternal diet (amount of fibers in maternal diet and based on this it will evaluate the variations in short chain fatty acids concentration) | Relationship between short chain fatty acids in breast milk and maternal diet will be measured by assessing the amount of fibers in maternal diet and based on this it will evaluate the variations in short chain fatty acids concentration. These assessments will be carried out by using a food diary carefully compiled by mothers before each sampling of breast milk |
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Inclusion Criteria:
Exclusion Criteria:
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parturients women at term hospitalized in the Department of Obstetrics, Gynecology and Pathophysiology of Human Reproduction, "Federico II" University of Naples.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Annalisa Passariello, MD, PhD | Contact | + 39 081 746 2680 | annalisa.passariello@unina.it | |
| roberto berni canani, MD, PhD | Contact | + 39 081 746 2680 | berni@unina.it |
| Name | Affiliation | Role |
|---|---|---|
| Annalisa Passariello, MD, PhD | "Federico II" University of Naples | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| "Federico II" University of Naples | Naples | Naples | 80131 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11427691 | Background | Topping DL, Clifton PM. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev. 2001 Jul;81(3):1031-64. doi: 10.1152/physrev.2001.81.3.1031. | |
| 12740060 | Background | Macfarlane S, Macfarlane GT. Regulation of short-chain fatty acid production. Proc Nutr Soc. 2003 Feb;62(1):67-72. doi: 10.1079/PNS2002207. |
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| 10 days after delivery and every 30 days until the fifth month after delivery |
| 11698242 | Background | Resta-Lenert S, Truong F, Barrett KE, Eckmann L. Inhibition of epithelial chloride secretion by butyrate: role of reduced adenylyl cyclase expression and activity. Am J Physiol Cell Physiol. 2001 Dec;281(6):C1837-49. doi: 10.1152/ajpcell.2001.281.6.C1837. |
| 7429343 | Background | Roediger WE. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut. 1980 Sep;21(9):793-8. doi: 10.1136/gut.21.9.793. |
| 11773614 | Background | Kunzelmann K, Mall M. Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev. 2002 Jan;82(1):245-89. doi: 10.1152/physrev.00026.2001. |
| 2925072 | Background | Binder HJ, Mehta P. Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology. 1989 Apr;96(4):989-96. doi: 10.1016/0016-5085(89)91614-4. |
| 6270094 | Background | Boffa LC, Gruss RJ, Allfrey VG. Manifold effects of sodium butyrate on nuclear function. Selective and reversible inhibition of phosphorylation of histones H1 and H2A and impaired methylation of lysine and arginine residues in nuclear protein fractions. J Biol Chem. 1981 Sep 25;256(18):9612-21. |
| 22103307 | Background | Belderbos ME, Houben ML, van Bleek GM, Schuijff L, van Uden NO, Bloemen-Carlier EM, Kimpen JL, Eijkemans MJ, Rovers M, Bont LJ. Breastfeeding modulates neonatal innate immune responses: a prospective birth cohort study. Pediatr Allergy Immunol. 2012 Feb;23(1):65-74. doi: 10.1111/j.1399-3038.2011.01230.x. Epub 2011 Nov 22. |