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This is a randomized Phase III study to evaluate efficancy of weekly cisplatin or nedaplatin concurrent with Intensity-modulated radiation therapy in Nasopharyngeal Carcinoma (NPC).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low dose cisplatin arm | Active Comparator | concurrent chemotherapy: cisplatin 20mg/m2,weekly,for 6 cycles during radiotherapy |
|
| High dose cisplatin arm | Active Comparator | concurrent chemotherapy: cisplatin 30mg/m2,weekly,for 6 cycles during radiotherapy |
|
| Low dose nedaplatin arm | Experimental | concurrent chemotherapy: nedaplatin 20mg/m2,weekly,for 6 cycles during radiotherapy |
|
| High dose nedaplatin arm | Experimental | concurrent chemotherapy: nedaplatin 30mg/m2,weekly,for 6 cycles during radiotherapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nedaplatin | Drug | Nedaplatin combine with IMRT |
|
| Measure | Description | Time Frame |
|---|---|---|
| Response rate | 2 years | |
| Progress-free survival | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Tumor response | radiotherapy in 2 week、4 week、7 week | |
| Overall survival | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Li Yin, M.D. Ph.D. | Contact | +8613913909043 | yinli7878@sina.com | |
| Pengwei Yan, M.M. | Contact | +8613815888775 | 179032794@qq.com |
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| ID | Term |
|---|---|
| D000077274 | Nasopharyngeal Carcinoma |
| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| C053989 | nedaplatin |
| D002945 | Cisplatin |
| ID | Term |
|---|---|
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
| D017671 | Platinum Compounds |
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| Cisplatin | Drug | Cisplatin combine with IMRT |
|
|
| D009303 |
| Nasopharyngeal Neoplasms |
| D010610 | Pharyngeal Neoplasms |
| D010039 | Otorhinolaryngologic Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
| D009302 | Nasopharyngeal Diseases |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
| D010038 | Otorhinolaryngologic Diseases |