Safety and Efficacy of Baclofen for Treatment of Muscle Spasms in Patients With Cirrhosis: A Pilot Study

Safety and Efficacy of Baclofen for Treatment of Muscle Spasms in Patients With Cirrhosis: A Pilot Study

The purpose of this study is to determine the safety and efficacy of the medication Baclofen for treatment of muscle cramps in patients with cirrhosis.

Inclusion Criteria:

• Cirrhosis
• Presence of muscle cramps on a regular basis

Exclusion Criteria:

• Allergy or hypersensitivity to Baclofen
• Active or untreated Portosystemic encephalopathy
• Active alcohol or substance abuse
• Age less than 18
• Pregnancy
• Concomitant use of narcotic pain medication, other muscle relaxer, or other anti-spastic agent
• Concomitant use of Tricyclic Antidepressant due to drug interaction
• History of chronic kidney disease defined by GFR < 30 (using MDRD equation)
• Subject is institutionalized or a prisoner
• Inability or unwillingness to give informed consent
• Expected lifespan less than 3 months
• Severe or poorly controlled coexisting medical conditions or other significant issues as determined by the principal investigator to hinder the ability to adhere to study protocols