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Main purpose of this study is to evaluate efficacy of allogenic adipose-derived mesenchymal stem cells in treatment of tendon injury. ALLO-ASC will be administrated to the patients with supraspinatus partial thickness tear by ultrasonographic guided injection.
Injection volume depends on the size of lesion on ultrasound examination. And all injection will be done under ultrasound guidance. Double blind Randomized placebo controlled study will be done with following 3 groups. Each group will have 8 people, so, the total patients will be 24 people.
The investigators will compare the efficacy difference with VAS(visual analog scale, primary outcome), ASES(American Shoulder and Elbow Surgeons) Score, UCLA(University of California, Los Angles) Shoulder Score, DASH(The Disabilities of the Arm, Shoulder and Hand) Score and change of tear size compared to the baseline image assessed by MRI. These measurement will be done at 6 and 12 weeks after injections and long-term follow-up will be also planned to 6 months, 12months and 24 months except for the evaluation of the tear size which will be done at baseline, 3 months and 24 months after the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mesenchymal stem cell group | Experimental | Received allogenic adipose tissue-derived adult mesenchymal stem cells (10million cells) in fibrin glue scaffold. |
|
| Active control (fibrin glue) group | Active Comparator | Received fibrin glue and normal saline. |
|
| Control (normal saline )group | Placebo Comparator | Received only normal saline. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| allogenic adipose stem cell injection | Biological | Intervention will be done with stem cell injection, 0.5cc (Total: 10 million cells), fibrin glue injection 0.5cc and range of motion exercise. |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Pain During Activity From Baseline to 3 Months After Intervention | Pain during activity will be evaluated by visual analog scale (active pain VAS). The active pain visual analog scale change from baseline to 3 months after intervention is the primary outcome. Visual analog scale is scored 0 to 10, higher scored meaning worse outcome. Negative values in change of pain during activity indicate improvement in pain. | Baseline and 3 months after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Pain During Rest | Pain during rest assessed by visual analog scale (VAS), scored 0 to 10, higher scores meaning worse outcome. | Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention |
| Pain During Activity |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sun Gun Chung, MD, PhD | Seoul National University College of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University College of Medicine | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22244061 | Background | Isaac C, Gharaibeh B, Witt M, Wright VJ, Huard J. Biologic approaches to enhance rotator cuff healing after injury. J Shoulder Elbow Surg. 2012 Feb;21(2):181-90. doi: 10.1016/j.jse.2011.10.004. | |
| 24057354 | Background | Muller SA, Todorov A, Heisterbach PE, Martin I, Majewski M. Tendon healing: an overview of physiology, biology, and pathology of tendon healing and systematic review of state of the art in tendon bioengineering. Knee Surg Sports Traumatol Arthrosc. 2015 Jul;23(7):2097-105. doi: 10.1007/s00167-013-2680-z. Epub 2013 Sep 21. |
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Volunteers were screened by a experienced physiatrist prior to enrollment. Of 26 potential participants, one refused to participate and another had incompatible findings in the baseline MRI. As a result, 24 participants met the inclusion/exclusion criteria and were enrolled and randomized to treatment.
Recruitment flyers were posted in a tertiary hospital and volunteers were recruited between September 2014 and April 2016. The first participant was enrolled on January 13, 2015 and the last participant was enrolled in April 12. 2016.
Not provided
| ID | Title | Description |
|---|---|---|
| FG000 | Mesenchymal Stem Cell Group | Received allogenic adipose tissue-derived adult mesenchymal stem cells (10million cells) in fibrin glue scaffold. allogenic adipose stem cell injection: Intervention will be done with stem cell injection, 0.5cc (Total: 10 million cells), fibrin glue injection 0.5cc and range of motion exercise. Eight participants were assigned and one declined to participate before the intervention. |
| Title | Milestones | Reasons Not Completed | |||||
|---|---|---|---|---|---|---|---|
| Overall Study |
|
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|
| fibrin glue/normal saline injection | Biological | Total 1cc of fibin glue and normal saline mixture injection and range of motion exercise |
|
|
| normal saline injection | Biological | Total 1cc of normal saline injection and range of motion exercise |
|
|
Pain during activity assessed by visual analog scale (VAS), scored 0 to 10, higher scores meaning worse outcome
| Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention |
| American Shoulder and Elbow Surgeons (ASES) Shoulder Score | Functional score of the shoulder was assessed by American Shoulder and Elbow Surgeons shoulder score which is a questionnaire dedicated to the functional evaluation of the shoulder. It is scored from 0 to 100, higher scores meaning better outcome. | Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention |
| Disability of Arm, Shoulder and Hand (DASH) Score | Shoulder function is assessed by DASH score which is questionnaire dedicated to evaluate the function of the upper extremity. It is scored from 0 (no disability) to 100 (most severe disability). | Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention |
| University of California, Los Angeles(UCLA) Shoulder Score | Shoulder function is assessed by UCLA shoulder score which is a composite of range of motion examination and questionnaire dedicated to evaluate the function of the shoulder. It is scored from 0 to 35, higher scores meaning better shoulder function. | Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention |
| Tear Size at 3 Months After Injection | Tear size was evaluated by 3-point Likert scale using MRI. The 3months follow-up images were compared to the baseline image and graded either; improved, stationary, and aggravated. | baseline and 3 months after intervention |
| Tear Size at 12 Months After Injection | Tear size was evaluated by 3-point Likert scale using MRI. The 12 months follow-up images were compared to the baseline image and graded either; improved, stationary, and aggravated. | baseline and12 months after intervention |
| 23040548 | Background | Tashjian RZ. Epidemiology, natural history, and indications for treatment of rotator cuff tears. Clin Sports Med. 2012 Oct;31(4):589-604. doi: 10.1016/j.csm.2012.07.001. Epub 2012 Aug 30. |
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| 17099241 | Background | Sanchez M, Anitua E, Azofra J, Andia I, Padilla S, Mujika I. Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med. 2007 Feb;35(2):245-51. doi: 10.1177/0363546506294078. Epub 2006 Nov 12. |
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| 20448192 | Background | Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T. Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med. 2010 Feb;38(2):255-62. doi: 10.1177/0363546509355445. |
| 21570659 | Background | Randelli P, Arrigoni P, Ragone V, Aliprandi A, Cabitza P. Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up. J Shoulder Elbow Surg. 2011 Jun;20(4):518-28. doi: 10.1016/j.jse.2011.02.008. |
| 18608363 | Background | Randelli PS, Arrigoni P, Cabitza P, Volpi P, Maffulli N. Autologous platelet rich plasma for arthroscopic rotator cuff repair. A pilot study. Disabil Rehabil. 2008;30(20-22):1584-9. doi: 10.1080/09638280801906081. |
| 19443990 | Background | Mizuno H. Adipose-derived stem cells for tissue repair and regeneration: ten years of research and a literature review. J Nippon Med Sch. 2009 Apr;76(2):56-66. doi: 10.1272/jnms.76.56. |
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| 19941450 | Background | Uysal AC, Mizuno H. Tendon regeneration and repair with adipose derived stem cells. Curr Stem Cell Res Ther. 2010 Jun;5(2):161-7. doi: 10.2174/157488810791268609. |
| 14578098 | Background | Gimble J, Guilak F. Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy. 2003;5(5):362-9. doi: 10.1080/14653240310003026. |
| 12475952 | Background | Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002 Dec;13(12):4279-95. doi: 10.1091/mbc.e02-02-0105. |
| 12928709 | Background | Mizuno H, Hyakusoku H. Mesengenic potential and future clinical perspective of human processed lipoaspirate cells. J Nippon Med Sch. 2003 Aug;70(4):300-6. doi: 10.1272/jnms.70.300. |
| 15604532 | Background | von Heimburg D, Hemmrich K, Haydarlioglu S, Staiger H, Pallua N. Comparison of viable cell yield from excised versus aspirated adipose tissue. Cells Tissues Organs. 2004;178(2):87-92. doi: 10.1159/000081719. |
| 16118291 | Background | Smith RK, Webbon PM. Harnessing the stem cell for the treatment of tendon injuries: heralding a new dawn? Br J Sports Med. 2005 Sep;39(9):582-4. doi: 10.1136/bjsm.2005.015834. No abstract available. |
| 17200313 | Background | Chong AK, Ang AD, Goh JC, Hui JH, Lim AY, Lee EH, Lim BH. Bone marrow-derived mesenchymal stem cells influence early tendon-healing in a rabbit achilles tendon model. J Bone Joint Surg Am. 2007 Jan;89(1):74-81. doi: 10.2106/JBJS.E.01396. |
| 12857411 | Background | Ouyang HW, Goh JC, Thambyah A, Teoh SH, Lee EH. Knitted poly-lactide-co-glycolide scaffold loaded with bone marrow stromal cells in repair and regeneration of rabbit Achilles tendon. Tissue Eng. 2003 Jun;9(3):431-9. doi: 10.1089/107632703322066615. |
| 18593247 | Background | Nixon AJ, Dahlgren LA, Haupt JL, Yeager AE, Ward DL. Effect of adipose-derived nucleated cell fractions on tendon repair in horses with collagenase-induced tendinitis. Am J Vet Res. 2008 Jul;69(7):928-37. doi: 10.2460/ajvr.69.7.928. |
| 19684297 | Background | Gulotta LV, Kovacevic D, Ehteshami JR, Dagher E, Packer JD, Rodeo SA. Application of bone marrow-derived mesenchymal stem cells in a rotator cuff repair model. Am J Sports Med. 2009 Nov;37(11):2126-33. doi: 10.1177/0363546509339582. Epub 2009 Aug 14. |
| 18683070 | Background | Del Bue M, Ricco S, Ramoni R, Conti V, Gnudi G, Grolli S. Equine adipose-tissue derived mesenchymal stem cells and platelet concentrates: their association in vitro and in vivo. Vet Res Commun. 2008 Sep;32 Suppl 1:S51-5. doi: 10.1007/s11259-008-9093-3. |
| 21773831 | Background | Ellera Gomes JL, da Silva RC, Silla LM, Abreu MR, Pellanda R. Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells. Knee Surg Sports Traumatol Arthrosc. 2012 Feb;20(2):373-7. doi: 10.1007/s00167-011-1607-9. Epub 2011 Jul 20. |
| 22185824 | Background | MacIsaac ZM, Shang H, Agrawal H, Yang N, Parker A, Katz AJ. Long-term in-vivo tumorigenic assessment of human culture-expanded adipose stromal/stem cells. Exp Cell Res. 2012 Feb 15;318(4):416-23. doi: 10.1016/j.yexcr.2011.12.002. Epub 2011 Dec 13. |
| 22065114 | Background | Guadalajara H, Herreros D, De-La-Quintana P, Trebol J, Garcia-Arranz M, Garcia-Olmo D. Long-term follow-up of patients undergoing adipose-derived adult stem cell administration to treat complex perianal fistulas. Int J Colorectal Dis. 2012 May;27(5):595-600. doi: 10.1007/s00384-011-1350-1. Epub 2011 Nov 9. |
| 18267891 | Background | Guest DJ, Smith MR, Allen WR. Monitoring the fate of autologous and allogeneic mesenchymal progenitor cells injected into the superficial digital flexor tendon of horses: preliminary study. Equine Vet J. 2008 Mar;40(2):178-81. doi: 10.2746/042516408X276942. |
| 16968862 | Background | Shiri R, Viikari-Juntura E, Varonen H, Heliovaara M. Prevalence and determinants of lateral and medial epicondylitis: a population study. Am J Epidemiol. 2006 Dec 1;164(11):1065-74. doi: 10.1093/aje/kwj325. Epub 2006 Sep 12. |
| 18725118 | Background | Hohendorff B, Siepen W, Spiering L, Staub L, Schmuck T, Boss A. Long-term results after operatively treated Achilles tendon rupture: fibrin glue versus suture. J Foot Ankle Surg. 2008 Sep-Oct;47(5):392-9. doi: 10.1053/j.jfas.2008.05.006. Epub 2008 Jul 14. |
| 24403741 | Background | Minagawa H, Yamamoto N, Abe H, Fukuda M, Seki N, Kikuchi K, Kijima H, Itoi E. Prevalence of symptomatic and asymptomatic rotator cuff tears in the general population: From mass-screening in one village. J Orthop. 2013 Feb 26;10(1):8-12. doi: 10.1016/j.jor.2013.01.008. eCollection 2013. |
| 23921338 | Background | Jo CH, Shin JS, Lee YG, Shin WH, Kim H, Lee SY, Yoon KS, Shin S. Platelet-rich plasma for arthroscopic repair of large to massive rotator cuff tears: a randomized, single-blind, parallel-group trial. Am J Sports Med. 2013 Oct;41(10):2240-8. doi: 10.1177/0363546513497925. Epub 2013 Aug 6. |
| 24129058 | Background | Oh JH, Chung SW, Kim SH, Chung JY, Kim JY. 2013 Neer Award: Effect of the adipose-derived stem cell for the improvement of fatty degeneration and rotator cuff healing in rabbit model. J Shoulder Elbow Surg. 2014 Apr;23(4):445-55. doi: 10.1016/j.jse.2013.07.054. Epub 2013 Oct 12. |
| 19450309 | Background | Buchbinder R, Green SE, Struijs P. Tennis elbow. BMJ Clin Evid. 2008 May 28;2008:1117. |
| 16118152 | Background | Levin D, Nazarian LN, Miller TT, O'Kane PL, Feld RI, Parker L, McShane JM. Lateral epicondylitis of the elbow: US findings. Radiology. 2005 Oct;237(1):230-4. doi: 10.1148/radiol.2371040784. Epub 2005 Aug 18. |
| 35039529 | Derived | Chun SW, Kim W, Lee SY, Lim CY, Kim K, Kim JG, Park CH, Hong SH, Yoo HJ, Chung SG. A randomized controlled trial of stem cell injection for tendon tear. Sci Rep. 2022 Jan 17;12(1):818. doi: 10.1038/s41598-021-04656-z. |
| FG001 | Active Control (Fibrin Glue) Group | Received fibrin glue and normal saline. fibrin glue/normal saline injection: Total 1cc of fibin glue and normal saline mixture injection and range of motion exercise Eight participants were assigned and followed up throughout the study. |
| FG002 | Control (Normal Saline )Group | Received only normal saline. normal saline injection: Total 1cc of normal saline injection and range of motion exercise Eight participants were assigned and followed up throughout the study except one who missed the last visit. |
| Intervention |
|
| COMPLETED |
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| NOT COMPLETED |
|
|
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | Mesenchymal Stem Cell Group | Received allogenic adipose tissue-derived adult mesenchymal stem cells (10million cells) in fibrin glue scaffold. allogenic adipose stem cell injection: Intervention will be done with stem cell injection, 0.5cc (Total: 10 million cells), fibrin glue injection 0.5cc and range of motion exercise. |
| BG001 | Active Control (Fibrin Glue) Group | Received fibrin glue and normal saline. fibrin glue/normal saline injection: Total 1cc of fibin glue and normal saline mixture injection and range of motion exercise |
| BG002 | Control (Normal Saline )Group | Received only normal saline. normal saline injection: Total 1cc of normal saline injection and range of motion exercise |
| BG003 | Total | Total of all reporting groups |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean | Standard Deviation | years |
| |||||||||||||||
| Sex: Female, Male | Count of Participants | Participants |
| ||||||||||||||||
| Region of Enrollment | Number | participants |
| ||||||||||||||||
| Pain during activity | Visual Analog Scale, scored from 0 to 10, higher score meaning worse outcome. | Mean | Standard Deviation | units on a scale |
| ||||||||||||||
| Pain during rest | Visual Analog Scale, scored from 0 to 10, higher score meaning worse outcome. | Mean | Standard Deviation | units on a scale |
| ||||||||||||||
| American Shoulder and Elbow Surgeons (ASES) Shoulder Score | American Shoulder and Elbow Surgeons score, scored from 0 to 100, with higher scores indicating better outcomes | Mean | Standard Deviation | units on a scale |
| ||||||||||||||
| University of California, Los Angeles(UCLA) Shoulder Score | University of California, Los Angeles(UCLA) Shoulder Score, range from 0 to 35 with a score of 0 indicating worse shoulder function and 35 indicating better shoulder function. | Mean | Standard Deviation | units on a scale |
| ||||||||||||||
| The Disabilities of the Arm, Shoulder and Hand(DASH) Score | The Disabilities of the Arm, Shoulder and Hand(DASH) Score, scored 0 to 100, lower score meaning better outcome. | Mean | Standard Deviation | units on a scale |
|
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Change of Pain During Activity From Baseline to 3 Months After Intervention | Pain during activity will be evaluated by visual analog scale (active pain VAS). The active pain visual analog scale change from baseline to 3 months after intervention is the primary outcome. Visual analog scale is scored 0 to 10, higher scored meaning worse outcome. Negative values in change of pain during activity indicate improvement in pain. | Posted | Mean | Standard Deviation | units on a scale | Baseline and 3 months after intervention |
|
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| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Pain During Rest | Pain during rest assessed by visual analog scale (VAS), scored 0 to 10, higher scores meaning worse outcome. | Posted | Mean | Standard Deviation | units on a scale | Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention |
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Pain During Activity | Pain during activity assessed by visual analog scale (VAS), scored 0 to 10, higher scores meaning worse outcome | Posted | Mean | Standard Deviation | units on a scale | Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention |
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | American Shoulder and Elbow Surgeons (ASES) Shoulder Score | Functional score of the shoulder was assessed by American Shoulder and Elbow Surgeons shoulder score which is a questionnaire dedicated to the functional evaluation of the shoulder. It is scored from 0 to 100, higher scores meaning better outcome. | Posted | Mean | Standard Deviation | score on a scale | Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention |
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Disability of Arm, Shoulder and Hand (DASH) Score | Shoulder function is assessed by DASH score which is questionnaire dedicated to evaluate the function of the upper extremity. It is scored from 0 (no disability) to 100 (most severe disability). | Posted | Mean | Standard Deviation | score on a scale | Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention |
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | University of California, Los Angeles(UCLA) Shoulder Score | Shoulder function is assessed by UCLA shoulder score which is a composite of range of motion examination and questionnaire dedicated to evaluate the function of the shoulder. It is scored from 0 to 35, higher scores meaning better shoulder function. | Posted | Mean | Standard Deviation | score on a scale | Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention |
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Tear Size at 3 Months After Injection | Tear size was evaluated by 3-point Likert scale using MRI. The 3months follow-up images were compared to the baseline image and graded either; improved, stationary, and aggravated. | Posted | Count of Participants | Participants | baseline and 3 months after intervention |
|
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| Secondary | Tear Size at 12 Months After Injection | Tear size was evaluated by 3-point Likert scale using MRI. The 12 months follow-up images were compared to the baseline image and graded either; improved, stationary, and aggravated. | Posted | Count of Participants | Participants | baseline and12 months after intervention |
|
|
2 years
All participants were asked the following open questions at every follow-up visit.
Not provided
| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Mesenchymal Stem Cell Group | Received allogenic adipose tissue-derived adult mesenchymal stem cells (10million cells) in fibrin glue scaffold. allogenic adipose stem cell injection: Intervention will be done with stem cell injection, 0.5cc (Total: 10 million cells), fibrin glue injection 0.5cc and range of motion exercise. Eight participants were assigned and one declined to participate before the intervention. | 0 | 7 | 0 | 7 | 7 | 7 |
| EG001 | Active Control (Fibrin Glue) Group | Received fibrin glue and normal saline. fibrin glue/normal saline injection: Total 1cc of fibin glue and normal saline mixture injection and range of motion exercise Eight participants were assigned and followed up throughout the study. | 0 | 8 | 0 | 8 | 8 | 8 |
| EG002 | Control (Normal Saline )Group | Received only normal saline. normal saline injection: Total 1cc of normal saline injection and range of motion exercise Eight participants were assigned and followed up throughout the study except one who missed the last visit. | 0 | 8 | 0 | 8 | 8 | 8 |
Not provided
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| insomnia | Psychiatric disorders | CTCAE (4.0) | Systematic Assessment |
| |
| conjunctivitis | Eye disorders | CTCAE (4.0) | Systematic Assessment |
| |
| back pain | Musculoskeletal and connective tissue disorders | CTCAE (4.0) | Systematic Assessment |
| |
| neck pain | Musculoskeletal and connective tissue disorders | CTCAE (4.0) | Systematic Assessment |
| |
| pain in extremity | Musculoskeletal and connective tissue disorders | CTCAE (4.0) | Systematic Assessment |
|
Not provided
Not provided
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Sun G. Chung | , Seoul National University Hospital | +82-2-2072-2560 | chung60611@gmail.com |
| ID | Term |
|---|---|
| D000070636 | Rotator Cuff Injuries |
| ID | Term |
|---|---|
| D012421 | Rupture |
| D014947 | Wounds and Injuries |
| D000070599 | Shoulder Injuries |
| D013708 | Tendon Injuries |
Not provided
Not provided
| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
Not provided
Not provided
| Male |
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