Impact of Fas/FasL in Chemotherapy Response in Epithelial Ovarian Carcinoma

Impact of Fas/FasL in Chemotherapy Response in Epithelial Ovarian Carcinoma

Ovarian carcinoma has poor prognosis and new therapeutic strategies are required. Many patients with ovarian carcinoma showed resistance to chemotherapy. Cleaved FasL is known for induced atypical response when is binding to Fas such as avoiding apoptosis and inducing cell motility.

Pre-Inclusion Criteria:

- Patient with suspicious ovarian carcinoma using clinical data, biological data (ca125) and radiological data (CT)

Inclusion Criteria:

• Pathological ovarian carcinoma diagnosed at pathological analysis after surgery.
• Neo adjuvant chemotherapy

Exclusion Criteria:

• no neo-adjuvant chemotherapy
• no ovarian carcinoma at final pathological analysis
• less than 18 years old.