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The aim of the investigators study was to investigate the safety and efficacy of autologous ADSCs for the clinical treatment of liver cirrhosis.
One milliliter of cell suspension will be injected intrahepatically under sonographic guidance using a gauge-18 needle.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ADSCs | Experimental | One milliliter of cell suspension will be injected intrahepatically under sonographic guidance using a gauge-18 needle. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ADSCs | Drug | autologous ADSCs |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| MELD | MELD uses the patient's values for serum bilirubin, serum creatinine, and the international normalized ratio for prothrombin time (INR) to predict survival. It is calculated according to the following formula:MELD = 3.78[Ln serum bilirubin (mg/dL)] + 11.2[Ln INR] + 9.57[Ln serum creatinine (mg/dL)] + 6.43. | 1-6 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| CMU B Hospital | China Medical University Beigang Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| China Medical University Beigang Hospital | Taichung | Beigang | 65152 | Taiwan | ||
| Gwo Xi Stem Cell Applied Technology Co., Ltd. |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22776464 | Background | Harn HJ, Lin SZ, Hung SH, Subeq YM, Li YS, Syu WS, Ding DC, Lee RP, Hsieh DK, Lin PC, Chiou TW. Adipose-derived stem cells can abrogate chemical-induced liver fibrosis and facilitate recovery of liver function. Cell Transplant. 2012;21(12):2753-64. doi: 10.3727/096368912X652959. Epub 2012 Jul 5. |
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CRO
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| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
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| Hsinchu |
| 30261 |
| Taiwan |
| D013568 |
| Pathological Conditions, Signs and Symptoms |