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This study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD. Evaluate the differences of prognosis between the different oxidative stress level (according to the level of ROMs are divided into higher and normal phenotype). Explore the new oxidative stress evaluation index ROMs application value in COPD.
Reactive oxygen metabolites (reactive oxygen metabolites, ROMs) test is a method by measuring the total reactive oxygen metabolites (ROMs) content in blood so as to evaluate the overall level of oxidative stress in the human body .Our previous studies have established the method of detecting ROMs which is suitable for fully automatic biochemical analyser.Our study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD. Evaluate the differences of prognosis between the different oxidative stress level (according to the level of ROMs are divided into higher and normal phenotype). Explore the new oxidative stress evaluation index ROMs application value in COPD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stability in patients with COPD | Those patients diagnosed COPD according to the GOLD guideline and without acute exacerbation within one month. | ||
| AECOPD | the diagnosis of an exacerbation relies exclusively on the clinical presentation of the patient complaining of an acute change of symptoms (baseline dyspnea, cough, and/or sputum production) that is beyond normal day-to-day variation. | ||
| Healthy persons without smoking | The healthy people who do not smoke | ||
| Healthy persons with smoking | Healthy persons who smoke |
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| Measure | Description | Time Frame |
|---|---|---|
| The different levels of the ROMs among different groups | Apply the analysis of variance to compare the different levels of ROMs among the four different groups | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| The differences of the ROMs among the different lung function levels in the stable stage of COPD group | Apply the analysis of variance to compare the differences of the ROMs among the lung function levels in the stable stage of COPD group. | 3 years |
| The relevance of the ROMs with the lung function levels in the stable stage of COPD group |
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Inclusion Criteria:
Exclusion Criteria:
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Chaoyang hospital clinic
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ting Yang, Doctor | Contact | 13651380809 | dryangting@qq.com | |
| Jie Liu, Master | Contact | 18811225394 | chaoyangliujie@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Ting Yang, Doctor | Respiratory Institute, Beijing chaoyang hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Respiratory Institute;Beijing chaoyang hospital | Recruiting | Beijing | Beijing Municipality | 100020 | China |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Serum
Apply Pearson correlation to compare relevance the of the ROMs with the lung function levels in the stable stage of COPD group. |
| 3 years |
| The relevance of the ROMs with the score of mMRC in the stable stage of COPD group | Apply Pearson correlation to compare relevance the of the ROMs with score of mMRC in the stable stage of COPD group. | 3 years |
| The relevance of the ROMs with the score of CAT in the stable stage of COPD group | Apply Pearson correlation to compare relevance the of the ROMs with score of CAT in the stable stage of COPD group. | 3 years |
| The relevance of the ROMs with the numbers of exacerbation in the stable stage of COPD group | Apply Pearson correlation to compare relevance the of the ROMs with numbers of exacerbation in the stable stage of COPD group. | 3 years |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |