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Cervical transforaminal epidural steroid injections (TFESI) are indicated in cervical radicular pain resistant to conservation therapy, by which steroids can be delivered into anterior epidural space surrounding target spinal nerve roots to help alleviate pain in the upper limb or neck. Cervical TFESI is traditionally commended to perform with guidance of fluoroscopy or CT. As fluoroscopy can not monitor the injection route whether it pass vessel or not, many serious neurological complications caused by inadvertent intra-arterial injection have been reported2. Here, the investigators will introduce a novel cervical TFESI guided by ultrasound, which incidence of inadvertent vessel injury or injection might be lower than those guided by fluoroscopy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| USNR steroid injection | Experimental | the patient who are treated with steroid (dexamethasone) injection through selected cervical spinal nerve block approach guided by ultrasound and C arm. |
|
| UCTF steroid injection | Experimental | the patients who are treated with steroid (dexamethasone) injection through cervical transforaminal approach guided by ultrasound and C arm. |
|
| XCTF steroid injection | Experimental | the patients who are treated with steroid (dexamethasone) injection through cervical transforaminal approach guided only by C arm. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SNR steroid (dexamethasone) injection | Procedure | deliver steroids (dexamethasone) into spinal nerve root with the guidance of ultrasound. Device: Ultrasound (S-Nerve; SonoSite, Bothell, Wash), Probe 9L (6 MHz, SonoSite, Bothell, Wash) |
| Measure | Description | Time Frame |
|---|---|---|
| change of pain severity rated on a Visual Analog Scale (VAS) | 1 day before, 1day after, 1week after and 4 weeks after the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| change of neck actives rated on Neck Disability Index (NDI) | 1 day before, 1day after, 1week after and 4 weeks after the intervention | |
| change of medication use rated on Medication Quantitative Scale (MQS) | 1 day before, 1day after, 1week after and 4 weeks after the intervention |
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Inclusion Criteria:
Exclusion criteria:
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| ID | Term |
|---|---|
| D011843 | Radiculopathy |
| ID | Term |
|---|---|
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D003907 | Dexamethasone |
| D007267 | Injections |
| D014463 | Ultrasonography |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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| CTF steroid (dexamethasone) injection | Procedure | deliver steroids (dexamethasone) into spinal epidural space with the guidance of ultrasound. Device: Ultrasound (S-Nerve; SonoSite, Bothell, Wash), Probe 9L (6 MHz, SonoSite, Bothell, Wash) |
|
| Dexamethasone | Drug | One of the most efficient steroids |
|
|
| Ultrasound | Device | Ultrasound (S-Nerve; SonoSite, Bothell, Wash), Probe 9L (6 MHz, SonoSite, Bothell, Wash) |
|
| C arm | Radiation | the needle position will be re-confirmed by C arm C arm (Philips Healthcare, Best, the Netherlands) |
|
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D004333 | Drug Administration Routes |
| D004358 | Drug Therapy |
| D013812 | Therapeutics |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |