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The primary aim of this study is to compare traditional muscle function tests with computerized versions using body-worn motion sensors and video motion analysis of the same tests. The investigators selected the Timed Up and Go (TUG) test as the investigators primary variable for this aim with several other function tests (e.g., repeated chair rise, 6-meter walk, 2-minute walk, Romberg stance, semi-tandem / tandem stance) as secondary variables. The investigators primary hypothesis is that the computerized versions of the TUG test are highly correlated (>0.9) with the traditional method, but with comparable or better reproducibility. Secondary analyses will correlate other function tests with their computerized version, again with the hypothesis that they are highly correlated and that computerized versions are of similar or better reproducibility. This analysis will also compare traditional assessments of balance with a computerized balance method, computerized dynamic posturography.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | This is an observational trial, no interventions are being used. |
| Measure | Description | Time Frame |
|---|---|---|
| The comparison of results of traditional physical function tests with the results of computerized versions (body worn sensors and Kinect system) of the same tests. | Short-term reproducibility of traditional vs. computerized functional tests will also be compared. | All physical function tests will be performed at the first visit and visit 2 up to 4 days later |
| Measure | Description | Time Frame |
|---|---|---|
| Explore the capabilities of the Microsoft Kinect system to record and analyze muscle function tests and correlate the Microsoft Kinect system to a gold standard motion analysis system. | All physical function tests will be performed at the first visit and visit 2 up to 4 days later. | |
| Validate the use of BIS (Bioelectrical Impedance Spectroscopy) to adjust DXA (Dual Energy X-ray Absorptiometry) -measured body composition by providing muscle mass measurement |
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Inclusion Criteria:
Exclusion Criteria:
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This study will evaluate community dwelling women and men ≥ 70 years recruited from the Madison, Wisconsin area.
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| Name | Affiliation | Role |
|---|---|---|
| Neil Binkley, M.D. | University of Wisconsin, Madison | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Wisconsin-Madison Osteoporosis Clinical Research Program | Madison | Wisconsin | 53705 | United States |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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Blood will be drawn to obtain a serum chemistry panel to document health status of the study participants. For subjects who agree to optional banking, serum aliquots will be obtained and banked for future study of markers relevant to musculoskeletal health.
The relationship of lean mass, as estimated by DXA and BIS with muscle mass as measured by deuterated creatine dilution as a nominal gold standard. Additionally, the correlation of lean mass as measured by DXA and muscle mass as measured by BIS and creatine dilution with muscle function tests. |
| BIS is performed at visit 1 and visit 2 up to 4 days later. DXA is performed at visit 2. |
| Correlate various ratios of lean or muscle mass / DXA measured fat mass with functional tests. | All physical function tests will be performed at the screen and follow up visits. |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |