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| Name | Class |
|---|---|
| Hanmi Pharmaceutical Company Limited | INDUSTRY |
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The purpose of this study is to investigate which combination therapy is more effective for improving the blood pressure (BP) and AM central SBP in hypertensive patients:Angiotensin II receptor blocker (ARB) plus calcium channel blocker (CCB) or ARB plus diuretics
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Losartan 50mg/amlodipine 5mg | Experimental | Once daily, 1T, PO medication |
|
| Losartan 100mg/amlodipine 5mg | Experimental | Once daily, 1T, PO medication |
|
| Losartan50 mg/Hydrochlorothiazide12.5 mg | Active Comparator | Once daily, 1T, PO medication |
|
| Losartan100 mg/Hydrochlorothiazide25 mg | Active Comparator | Once daily, 1T, PO medication |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Losartan 50mg/amlodipine 5mg | Drug | once daily, 1T, PO medication |
|
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in msSBP | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in AMcSBP | 20 weeks |
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Inclusion Criteria:
Exclusion Criteria:
- msDBP≥110mmHg or ms SBP ≥ 180mmHg at the screening and randomization visit
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| Name | Affiliation | Role |
|---|---|---|
| Chong-Jin Kim | Kyung Hee University Hospital at Gangdong | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kyung Hee University Hospital at Gangdong | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31099387 | Derived | Cho EJ, Lee HY, Sung KC, Park S, Sohn IS, Park CG, Choi DJ, Ha JW, Ahn YK, Shin J, Hong SJ, Kim SK, Chung WJ, Yoo BS, Hong TJ, Youn HJ, Cho MC, Chae SC, Kim YJ, Kim CJ. Comparison of 24-Hour Ambulatory Central Blood Pressure Reduction Efficacy Between Fixed Amlodipine or Up-Titrated Hydrochlorothiazide Plus Losartan: The K-Central Study. Am J Hypertens. 2019 Sep 24;32(10):992-1002. doi: 10.1093/ajh/hpz050. | |
| 28879040 |
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| Losartan 100mg/amlodipine 5mg | Drug | once daily, 1T, PO medication |
|
|
| Losartan 50mg/Hydrochlorothiazide 12.5mg | Drug | once daily, 1T, PO medication |
|
|
| Losartan 100mg/Hydrochlorothiazide 25mg | Drug | once daily, 1T, PO medication |
|
|
| Derived |
| Oh GC, Lee HY, Chung WJ, Youn HJ, Cho EJ, Sung KC, Chae SC, Yoo BS, Park CG, Hong SJ, Kim YK, Hong TJ, Choi DJ, Hyun MS, Ha JW, Kim YJ, Ahn Y, Cho MC, Kim SG, Shin J, Park S, Sohn IS, Kim CJ. Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active-controlled, phase 4, randomized trial. Clin Hypertens. 2017 Sep 4;23:18. doi: 10.1186/s40885-017-0074-0. eCollection 2017. |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D019808 | Losartan |
| D017311 | Amlodipine |
| D006852 | Hydrochlorothiazide |
| ID | Term |
|---|---|
| D001713 | Biphenyl Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D013777 | Tetrazoles |
| D004095 | Dihydropyridines |
| D011725 | Pyridines |
| D002740 | Chlorothiazide |
| D001581 | Benzothiadiazines |
| D013449 | Sulfonamides |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D049971 | Thiazides |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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