A Study of Lispro Formulations in Healthy Participants

Safety, Tolerability, and Pharmacokinetics of Multiple Novel Insulin Lispro Formulations

The purposes of this study are to determine:

• Part A

  • How quickly your body absorbs, breaks down and gets rid of the different formulations of insulin lispro compared to insulin lispro alone formulation.
  • The safety of insulin lispro in different formulations and any side effects that might be associated with it.

• Part B:

  • How much insulin lispro from different dose ranges is found in the bloodstream using a test insulin lispro formulation (selected from Part A).
  • The safety of insulin lispro in different formulations and any side effects that might be associated with it.

Participants may only enroll in one part. The study is expected to last up to 10 weeks for each part.

Inclusion Criteria:

- Overtly healthy males or females (non-childbearing potential and with absent cyclical hormonal changes), as determined by medical history and physical examination

Exclusion Criteria:

- Have a fasting plasma glucose less than or equal to (≤) 4.0 millimole per liter (mmol/L) at screening