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Over 24 hrs serum and plasma samples were collected every 3 hrs. With this a day histamine profile was created. 15 healthy persons with 20 patients with a high level of IgE in serum and 20 patients with afflictions but no high IgE level were compared. Measurment of histamine in plasma, urine and stool were realized. In addition to that Diaminoxidase, TNF alpha and IgE Antibodies were measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | healthy subjects |
| |
| IgE positive | patients with high IgE level in serum |
| |
| IBS patients | patients with afflictions, but no high IgE level and suspicion on histamine intolerance |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood profile | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Histamine | 24 hrs |
| Measure | Description | Time Frame |
|---|---|---|
| diaminoxidase | 24 hrs |
| Measure | Description | Time Frame |
|---|---|---|
| TNF alpha | 24 hrs | |
| IgE | 24 hrs |
Inclusion Criteria:
Exclusion Criteria:
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healthy subjects, patients with high IgE level and patients with afflictions, but no high IgE level
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitätsklinikum Erlangen | Erlangen | 91054 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29154390 | Derived | Pinzer TC, Tietz E, Waldmann E, Schink M, Neurath MF, Zopf Y. Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls. Allergy. 2018 Apr;73(4):949-957. doi: 10.1111/all.13361. Epub 2017 Dec 15. |
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| ID | Term |
|---|---|
| D006967 | Hypersensitivity |
| ID | Term |
|---|---|
| D007154 | Immune System Diseases |
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