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Aim: To investigate the dose-dependent vascular effect (primarily using FMD) of 3 low-level doses of pure (-)-epicatechin ≤ 1 mg/kg BW (0.1, 0.5 & 1.0 mg/kg BW) in healthy men.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0.1 mg/ kg BW pure (-)-epicatechin | Active Comparator | 0.1 mg/ kg BW pure (-)-epicatechin (according to volunteer) dissolved in 3 ml/kg BW of water. |
|
| 0.5 mg/ kg BW pure (-)-epicatechin | Active Comparator | 0.5 mg/ kg BW pure (-)-epicatechin (according to volunteer) dissolved in 3 ml/kg BW of water. |
|
| 1.0 mg/ kg BW pure (-)-epicatechin | Active Comparator | 1.0 mg/ kg BW pure (-)-epicatechin (according to volunteer) dissolved in 3 ml/kg BW of water. |
|
| 0.0 mg/ kg BW pure (-)-epicatechin | Placebo Comparator | Water only (3 ml/kg BW) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Water | Dietary Supplement | Control |
|
| Measure | Description | Time Frame |
|---|---|---|
| Flow mediated dilatation | baseline to 2h |
| Measure | Description | Time Frame |
|---|---|---|
| Laser Doppler Imaging with Iontophoresis | baseline to 2h | |
| Plasma (-)-epicatechin metabolites | baseline to 24h | |
| Plasma nitrate/nitrite |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeremy Spencer, PhD | University of Reading | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Food and Nutritional Sciences | Reading | Berkshire | RG6 6AP | United Kingdom |
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| ID | Term |
|---|---|
| D000783 | Aneurysm |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D014867 | Water |
| D002392 | Catechin |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 |
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| Epicatechin 0.1 mg/kg | Dietary Supplement | EC 0.1 mg/kg |
|
| Epicatechin 0.5 mg/kg | Dietary Supplement | EC 0.5 |
|
| Epicatechin 1.0 mg/kg | Dietary Supplement | EC 1.0 |
|
| baseline to 2h |
| Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |
| D002839 | Chromans |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D005419 | Flavonoids |
| D002867 | Chromones |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |