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The purpose of this study is to carry out a randomized double blind controlled trial in 30 male subjects to investigate the effect of acai consumption on acute changes in vascular function, and to other cardiovascular markers. As a secondary aim the study will allow us to characterize the absorption and metabolism of acai polyphenols in humans over a 24 hour period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 150g of acai fruit | Active Comparator | 150g of acai fruit in fruit smoothie form |
|
| Placebo control | Placebo Comparator | The control will be a smoothie-like drink matched for major macro- and micro-nutrients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acai puree, frozen blended it with banana | Dietary Supplement | 150g of acai fruit, frozen blended it with banana. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Flow-mediated dilation | Change from baseline to 2h |
| Measure | Description | Time Frame |
|---|---|---|
| plasma polyphenol metabolites | Change from baseline to 24h |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Commane, PhD | University of Reading | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hugh Sinclair Unit of Human Nutrition | Reading | Berkshire | RG6 6AP | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27680990 | Derived | Alqurashi RM, Galante LA, Rowland IR, Spencer JP, Commane DM. Consumption of a flavonoid-rich acai meal is associated with acute improvements in vascular function and a reduction in total oxidative status in healthy overweight men. Am J Clin Nutr. 2016 Nov;104(5):1227-1235. doi: 10.3945/ajcn.115.128728. Epub 2016 Sep 28. |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| Control Macronutrient matched | Dietary Supplement | Macronutrient matched control in water and also prepared with banana. |
|