Receptor Occupancy of ITI-007 Using Positron Emission Tomography (PET) in Patients With Stable Schizophrenia

An Open-Label Positron Emission Tomography (PET) Study to Demonstrate Receptor Occupancy, Safety, Tolerability and Pharmacokinetics of ITI-007 in Stable Schizophrenia Patients

The purpose of this study is to determine the relationship between ITI-007 dose, plasma levels and brain receptor occupancy in patients with stable schizophrenia.

Inclusion Criteria:

• Patients with schizophrenia who are drug-free with regard to their antipsychotic medication
• In clinical remission and free from acute exacerbation of their psychosis
• In good health

Exclusion Criteria:

• Clinically significant medical conditions considered inappropriate for trial participation