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The purpose of the study is to evaluate whether variability of CPP (cerebral perfusion pressure) is related to sepsis-associated encephalopathy and outcomes of patients with sepsis.
Encephalopathy is a common complication of sepsis, impaired cerebrovascular autoregulation (AR) in patients with sepsis is considered related to Sepsis-associated encephalopathy (SAE). As AR is important in stabilizing the cerebral perfusion pressure, whether greater variability of CPP is related to SAE and mortality or not remains unclear. We conduct this study to evaluate the relationship between them.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SAE | patient who develop encephalopathy in the progress of sepsis |
| |
| non-SAE | patient who do not develop encephalopathy in the progress of sepsis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no interventions | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| relationship between cerebral perfusion pressure variability and sepsis-associated encephalopathy | To estimate CPP noninvasively, we will monitor the middle cerebral artery flow velocity of patients with sepsis using transcranial Doppler ultrasound in the first 72h of their enrollment. Diagnosis of a SAE was performed using the confusion assessment method for ICU(CAM-ICU). | cerebral perfusion pressure is assessed up to 72 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of mechanical ventilation | All the participants will be followed up until discharge or death, assessed up to 24 months | |
| Time of ICU stay | All the participants will be followed up until discharge or death, assessed up to 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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all patients admit to the general ICU of an academic teaching hospital
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kang Yan | Chengdu | Sichuan | 610041 | China |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| D065166 | Sepsis-Associated Encephalopathy |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| Time of hospital stay | All the participants will be followed up until discharge or death, assessed up to 24 months |
| 90-day mortality rate | All the participants will be followed up until 90 days after their enrollment or death |
| 1-year mortality rate | All the participants will be followed up until 1 year after their enrollment or death |
| 2-year mortality rate | All the participants will be followed up until 2 years after their enrollment or death |
| 1-year quality of life of survivors | EQ-5D will be used to evaluate quality of life of survivors | All the participants will be followed up until 1 year after their enrollment or death |
| 2-year quality of life of survivors | EQ-5D will be used to evaluate quality of life of survivors | All the participants will be followed up until 2 year after their enrollment or death |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |