Relationship of Cerebral Perfusion Pressure Variability to Sepsis-associated Encephalopathy

Relationship of Cerebral Perfusion Pressure Variability to Sepsis-associated Encephalopathy

The purpose of the study is to evaluate whether variability of CPP (cerebral perfusion pressure) is related to sepsis-associated encephalopathy and outcomes of patients with sepsis.

Encephalopathy is a common complication of sepsis, impaired cerebrovascular autoregulation (AR) in patients with sepsis is considered related to Sepsis-associated encephalopathy (SAE). As AR is important in stabilizing the cerebral perfusion pressure, whether greater variability of CPP is related to SAE and mortality or not remains unclear. We conduct this study to evaluate the relationship between them.

Inclusion Criteria:

• clinical symptoms of sepsis, severe sepsis and septic shock
• age over 18 years

Exclusion Criteria:

• preexisting Neurological diseases
• traumatic brain injury
• intracranial infectious disease
• severe hepatic or renal dysfunction
• ICU discharge Within 72 hours
• pregnancy