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This study aims to test whether the addition of transcranial direct current stimulation (TDCS) to speech fluency training results in improvements in speech fluency in adults with developmental stuttering. Half of the participants will receive anodal TDCS on five consecutive days, the other half will receive a sham stimulation for the same amount of time.
Studies using TDCS have shown improvements in motor performance, and in expressive language skills in clinical and healthy populations. The benefits of single sessions of TDCS are short-lived. However, stimulation over multiple sessions can increase and prolong learning effects that can persist for several weeks after the end of the stimulation period. We aim to target left hemisphere frontal regions involved in speech production with TDCS, and to pair this stimulation with speech fluency training.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anodal TDCS | Experimental | Participants will receive anodal TDCS over the left inferior frontal cortex. TDCS will be delivered at 1milliampere (mA) intensity for 20 minutes during speech fluency training (5 consecutive days). |
|
| Sham TDCS | Sham Comparator | Participants will receive sham TDCS over the left inferior frontal cortex. Sham stimulation will involve 30 seconds stimulation at the beginning of the 20 minutes of speech fluency training (5 consecutive days). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anodal TDCS | Device | 20 minutes 1mA anodal stimulation to left inferior frontal cortex. Cathode positioned on right supra-orbital ridge. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline proportion of stuttering in speech sample | Quantitative measurement of stuttering | 1 week post-treatment |
| Change from baseline proportion of stuttering in speech sample | Quantitative measurement of stuttering | 6 weeks post-treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline on the Stuttering Severity Instrument version 4 (SSI-4) | Standardised assessment of frequency and duration of stuttering and associated physical concomitants | 1 week post-treatment |
| Change from baseline on the Stuttering Severity Instrument version 4 (SSI-4) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kate Watkins, PhD | University of Oxford | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Oxford | Oxford | OX1 3UD | United Kingdom |
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| Label | URL |
|---|---|
| Speech and Brain Research Group, University of Oxford | View source |
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| ID | Term |
|---|---|
| D013342 | Stuttering |
| D013064 | Speech Disorders |
| ID | Term |
|---|---|
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Fluency Training | Behavioral | Speech tasks will be completed using fluency-enhancing techniques: metronome-timed speech and auditory choral speech. |
|
Standardised assessment of frequency and duration of stuttering and associated physical concomitants |
| 6 weeks post-treatment |
| Change from baseline on Overall Assessment of Speaker's Experience of Stuttering (OASES) | Standardised assessment of the functional impact of stuttering on a person's life | 6 weeks post-treatment |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |