Pharmacokinetics of Selected Antiinfectives During Sustained Low-efficiency Dialysis (SLED)

Pharmacokinetics of Selected Antiinfectives During Sustained Low-efficiency Dialysis (SLED)

In a prospective, non-interventional, monocentric observational study the pharmacokinetic properties of selected antiinfective drugs during sustained low-efficiency dialysis (SLED) will be analyzed.

Antibiotic concentrations are measured whilst patients receive SLED for renal replacement therapy. The plasma specimens will be quantified using high Performance liquid chromatography (HPLC).

Primary endpoint:

- Plasma levels of antiinfectives during SLED

Secondary endpoints:

• mortality
• length of stay at the intensive care unit (ICU) and hospital
• clinical cure of infections

Inclusion criteria:

• age: > 18 years
• patients under SLED
• antiinfective treatment

exclusion criteria:

- missing informed consent

Inclusion Criteria:

• age: 18 or older
• patients receiving SLED and either meropenem or ceftazidim

Exclusion Criteria:

• missing informed consent