Efficacy of Intravenous Dexketoprofen and Tenoxicam on Propofol Associated Injection Pain

Propofol remains the most common drug for induction of general anaesthesia, although it causes considerable pain or discomfort on injection. Anesthesia providers have attempted a large number of remedies to prevent this pain on injection. Previously explored ideas include injecting propofol into larger veins, warming of the hand with hot packs, and intravenous pretreatment with numerous other medications. No studies to date have looked at the dexketoprofen and tenoxicam for the pretreatment of pain on injection caused by propofol. The investigators propose studying the use of dexketoprofen and tenoxicam for pretreatment of propofol related pain on injection.

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) physical status 1 and 2
• 18 - 65 years
• general anesthesia scheduled for elective surgery

Exclusion Criteria:

• age < 18 years, > 65 years
• pregnancy
• patients requiring a rapid sequence induction
• refusal to participate and patients already participating in another study
• allergy to study drugs
• communication difficulty
• psychiatric and neurolojic disorders
• use of analgesics or sedative drugs within 24 hours before surgery.
• emergency surgery
• history of drug or alcohol abuse
• ASA 3 and above