Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid

This study seeks to evaluate a treatment for multiple full thickness chondral lesions in the knee. Eligible subjects will undergo a microdrilling surgery and up to 12 post operative intra-articular injections of bone marrow aspirate concentrate (BMAC), platelet rich plasma (PRP) and hyaluronic acid (HA).

Inclusion Criteria: MRI-confirmed full-thickness unipolar or bipolar chondral lesion(s) from osteoarthritis.

Exclusion Criteria:

• Inflammatory arthritis
• Body mass index (BMI) greater than 35
• Presence of significant varus or valgus knee instability or unusually stiff knee
• Greater than 50% deviation of the mechanical axis
• Presence of active cardiac disease
• Presence of active pulmonary disease
• Prior septic arthritis of the involved joint
• Presence of active bacterial or Mycobacterial infection
• Presence of a known hypercoagulable state
• Pregnant or lactating females
• Subject known to be positive for hepatitis B, hepatitis C, or HIV
• Known allergy to hyaluronic acid
• Patients who are unable or unwilling to participate fully in post-operative physical therapy
• Patients with a contraindication to MRI scanning
• Any disorder that compromises ability to give consent or comply with study procedures
• Patients who are felt to be at significantly increased risk for elective orthopedic surgery
• Non-ambulatory patients
• Patients with cognitive impairment