The purpose of this study is to see if a radioactive substance called 18F-Fluorodeoxyglucose (18F- FDG), injected into the cervix during a PET/CT scan done before surgery can show us more clearly which lymph nodes in the pelvis (the area near your uterus and cervix) contain cancer.

Inclusion Criteria:

• The study population will include women with stage IB1 cervical cancer (any histologic subtype) deemed eligible for surgery, and women with a clinical stage I high-grade endometrial cancer planning to undergo surgical staging. High grade is defined by the following:

  • Uterine serous carcinoma
  • Clear cell endometrial carcinoma
  • Grade 3 endometrioid carcinoma
  • Endometrial carcinosarcoma
  • Clinical stage I grade 1-2 endometrial cancer also eligible with deep myoinvasion ≥ 50% shown on preop MRI and/or elevated preop CA-125 > 35 U/ml.

• Age ≥18 years

• Hemoglobin ≥10 g/dL

• Plasma albumin ≥3 g/dL

• GOG performance status ≤2

• Plasma glucose ≤200 mg/dL

• Plasma creatinine ≤1.6

• Well-controlled hypertension

• Medical clearance for surgery and considered an appropriate surgical candidate

• Negative serum pregnancy test, if of child-bearing potential

• If, based on surgeon's assessment, the patient is recommended to undergo surgical staging for histologically confirmed endometrial cancer or if IB1 cervical cancer is deemed eligible for surgical treatment of disease

• Participation in other research protocols does not exclude a patient from participation in this study

Exclusion Criteria:

• Hemoglobin <10 g/dL
• Plasma albumin <3 g/dL
• GOG performance status >2
• Plasma glucose >200 mg/dL
• Renal insufficiency with plasma creatinine >1.6
• Uncontrolled hypertension
• Patient does not meet medical clearance for surgery and is not considered an appropriate surgical candidate
• Pregnancy

For Stage 2:

• Patient who are unwilling or unable to undergo MRI including patients with contraindications to MRI such as the presence of cardiac pacemakers of non-compatible intracranial vascular clips, claustrophobia, inability to lie flat for the duration of the study etc.
• Patients with a metallic hip implant or any other metallic implant or device in the pelvis that might distort local magnetic field and compromise quality of MRI