Efficacy of Oral Probiotic Administration in Patients With Chronic Periodontitis

Efficacy of Oral Probiotic Administration in Clinical, Immunological and Microbiological Parameters of Patients With Chronic Periodontitis Treated With Non Surgical Periodontal Treatment.

The aim of this randomized placebo- controlled clinical trial is to evaluate the effects of Lactobacillus rhamnosus SP1- containing probiotic tablets as an adjunct to scaling and root planning (SRP).

Material and methods: Thirty six chronic periodontitis patients will be recruited and monitored clinically, immunologically and microbiologically at baseline, 3 and 6 months after therapy. All patients will receive scaling and root planning and randomly will be assigned over an experimental (SRP + probiotic, n=18) or control (SRP + placebo, n=18) group. The tablets will be used once per day during 3 months.

Inclusion Criteria:

• ≥14 natural teeth, excluding third molars
• ≥10 posterior teeth
• ≥35 years old
• ≥ 5 teeth with periodontal sites with probing depths ≥5mm, clinical attachment loss ≥3mm
• Bleeding on probing ≥20% of sites
• Extensive bone loss determined radiographically

Exclusion Criteria:

• Periodontal treatment before the time of examination
• Systemic illness
• Pregnancy
• Anticoagulant, antibiotics and non- steroid anti- inflammatory therapy in the 6-month period before the study