An RCT of Oseltamivir in Outpatients With CPD: A Pilot Study.

A Randomized Controlled Trial of Oseltamivir in Outpatients With Chronic Pulmonary Disease: a Pilot Study

The proposed pilot study will provide needed data to establish the feasibility of a conducting a large randomized controlled trial as to the effectiveness of the use of oseltamivir early in the course of influenza in outpatients with chronic pulmonary disease.

Inclusion Criteria:

• Clinic patients with physician diagnosed chronic obstructive pulmonary disease
• respirologist-diagnosed non-cystic fibrosis bronchiectasis and pulmonary fibrosis (based on appropriate clinical, exposure, and radiological criteria as per American Thoracic Society guidelines)
• Participants will be drawn from the respirology clinics and will be randomized if within 72 hours of meeting criteria for influenza-like illness

Exclusion Criteria:

• residents of nursing homes
• patients who are immunosuppressed
• patients on immunosuppressive does (15 mg or more) of prednisone for three weeks or longer