Alterations in Muscle After Total Knee Arthroplasty

Alterations in Skeletal Muscle Gene Expression Following Total Knee Arthroplasty

The overall goals of this work are: 1) to elucidate alterations in gene expression and downstream protein synthesis 2 weeks after Total Knee Arthroplasty (TKA) to better explain quadriceps muscle atrophy after TKA and 2) understand the mechanisms responsible for improved maintenance of muscle strength with Neuromuscular Electrical Stimulation (NMES) utilization. Furthermore, this investigation seeks to expand previous findings regarding attenuation of strength and functional performance deficits with NMES application to better understand how altered gene expression influences muscle function.

Inclusion Criteria:

• 50 to 75 years of age
• Scheduled for unilateral TKA at University of Colorado Hospital
• Diagnosed with osteoarthritis
• Cognitive status that allows patients to consistently comprehend and repeat back directions regarding the details of the study

Exclusion Criteria:

• Neurological, vascular or cardiac problems that significantly limit function
• BMI > 35
• Testosterone supplementation
• Pregnancy
• Anticoagulant therapy