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The purpose of this study is to determine whether the use of 0.2/1.2 microliter in-line filter reduces the incidence of severe vasoplegia comparing to the 5 microliter filter.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0.2/1.2 microliter filter | Use of 0.2/1.2 microliter filters for intravenous drug administration | ||
| 5 mircroliter filter | Use of 5 microliter filters for intravenous drug administration |
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| Measure | Description | Time Frame |
|---|---|---|
| Incidence of severe vasoplegia | participants will be followed for the duration of intensive care unit stay, an expected average of 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Organ dysfunction | Severity of organdysfunction (SOFA-Score), incidence and severity of respiratory failure (Horovitz- Index), incidence and severity of acute kidney failure (RIFLE criteria), incidence and severity of delirium | participants will be followed for the duration of intensive care unit stay, an expected average of 1 week |
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Inclusion Criteria:
Exclusion Criteria:
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All patients, which will be treated on the anaesthesiological/surgical ICU of the University Hospital Frankfurt between 2013 - 2014
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| Name | Affiliation | Role |
|---|---|---|
| Kai Zacharowski, M.D. | University Hospital Frankfurt. Department of Anesthesiology, Intensive-Care Medicine and Pain Therapy. | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31757216 | Derived | Schmitt E, Meybohm P, Herrmann E, Ammersbach K, Endres R, Lindau S, Helmer P, Zacharowski K, Neb H. In-line filtration of intravenous infusion may reduce organ dysfunction of adult critical patients. Crit Care. 2019 Nov 22;23(1):373. doi: 10.1186/s13054-019-2618-z. |
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| Inflammation |
Interleukin-6 |
| participants will be followed for the duration of intensive care unit stay, an expected average of 1 week |
| Duration of ICU and hospital stay | participants will be followed for the duration of intensive care unit/ hospital stay, an expected average of 1 or 4 week (s), respectively |
| In-hospital mortality | participants will be followed for the duration of hospital stay, an expected average of 4 weeks |
| Morbidity | Incidence of preoperative myocardial infarction, stroke, pneumonia, sepsis and acute kidney failure according to routine documentation | participants will be followed for the duration of hospital stay, an expected average of 4 weeks |