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Former studies revealed a distinct pattern of changes in circulation during deliberate apnea. Blood pressure rises significantly often accompanied by bradycardia. Further studies confirmed a massive increase of total vascular resistance as it also happens in shock to maintain perfusion of heart, lung and brain. This study is to determine the exact alterations of the cardiac function during this reaction, show the redistribution of blood volume in apnea and evaluate possible longterm effects on the central nervous system caused by repeated apnea via magnetic resonance imaging.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Deliberate Apnea Group | Experimental | Subjects undergo maximum apnea. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| magnetic resonance imaging (MRI) | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cardiac Function: Duration of Apnea | Alteration of cardiac function in subjects undergoing maximum apnea. | every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements |
| Mean Blood Flow Measurement Under Apnea Using MRI | Blood flow pattern in subjects undergoing maximum apnea. | Every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29909774 | Derived | Eichhorn L, Doerner J, Luetkens JA, Lunkenheimer JM, Dolscheid-Pommerich RC, Erdfelder F, Fimmers R, Nadal J, Stoffel-Wagner B, Schild HH, Hoeft A, Zur B, Naehle CP. Cardiovascular magnetic resonance assessment of acute cardiovascular effects of voluntary apnoea in elite divers. J Cardiovasc Magn Reson. 2018 Jun 18;20(1):40. doi: 10.1186/s12968-018-0455-x. |
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| ID | Title | Description |
|---|---|---|
| FG000 | Deliberate Apnea Group |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Deliberate Apnea Group | Subjects undergo maximum apnea. magnetic resonance imaging (MRI) |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Cardiac Function: Duration of Apnea | Alteration of cardiac function in subjects undergoing maximum apnea. | Posted | Mean | Standard Deviation | sec | every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements |
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All-Cause Mortality, Serious, and Other [Not Including Serious] Adverse Events were not monitored/assessed.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Deliberate Apnea Group | Subjects undergo maximum apnea and magnetic resonance imaging (MRI) was performed. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Jonas Doerner | University of Bonn | 017632817006 | jonas.doerner@ukb.uni-bonn.de |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Race and Ethnicity Not Collected | Race and Ethnicity were not collected from any participant. | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
|
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| Primary | Mean Blood Flow Measurement Under Apnea Using MRI | Blood flow pattern in subjects undergoing maximum apnea. | Posted | Mean | Standard Deviation | ml/s | Every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements |
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