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The action of one Stendo pulsating suit session will be evaluated on 24 patients referred to the hypertension consultations for essential hypertension treated but not stabilized. The effect of one Stendo pulsating suit session system will be mainly assessed on the peripheral cutaneous microcirculation and on the central arterial pressure.
The role of the endothelium in micro-vascular system is mediated by synthesis and release of numerous substances that act on the smooth muscle fibres. The release of these products is modulated, in turn, by various circulating molecules, by the autonomic nervous system and by local mechanical factors such as shear stress.
The essential hypertension is associated to increased risks of cardiovascular and stroke morbidity and mortality and constitutes a major cause of severe kidney failure. The essential hypertension is a complex and multi-factorial disease; the dysfunction of the endothelium is of a great importance in the physiopathology of this disease, concerning both the consequences of the increase of the blood pressure and the possible cause of the hypertension development.
The Stendo pulsating suit is expected to increase the cutaneous microcirculation measured by laser Doppler laser flowmetry and potentially to decrease the central blood pressure. Each patient will be his own witness and the clinical records will be assessed before, during when relevant, and after a pulsating suit session.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stendo pulsating suit System | Experimental | One 20 minutes Stendo pulsating suit session will be applied to the patient. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stendo pulsating suit System | Device | The Stendo system, a multilayer pulsatile inflatable suit is applied to the lower limbs and the abdomen. This device induces a sequential compartmentalized compression synchronized with each diastolic phase of the cardiac cycle, each phase evolving centripetally (lower limbs to abdomen). |
| Measure | Description | Time Frame |
|---|---|---|
| Peripheral microcirculation measured using Laser Doppler flowmetry | Change in % of the peripheral cutaneous microcirculation using laser Doppler flowmetry after one Stendo pulsating suit session | 35 minutes after the end of the Stendo session at D1 + 7 jours +/- 3 |
| Measure | Description | Time Frame |
|---|---|---|
| Humeral arterial pressure | Humeral arterial pressure using automatic measures with Dinamap device | 20 minutes after the end of Stendo session at D1 + 7 jours +/- 3 |
| Central blood pressure | Central blood pressure measured by applanation using an applanation tonometry device; Central pulse pressure, Augmentation Index and subendocardial viability ratio will also be assessed. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guy AMAH, MD | Contact | +331 49 95 80 88 | guy.amah@lrb.aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Guy AMAH, MD | Service de Physiologie Clinique - Explorations Fonctionnelles | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Lariboisière - Service de Physiologie Clinique - Explorations Fonctionnelles | Recruiting | Paris | 75010 | France |
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| ID | Term |
|---|---|
| D000075222 | Essential Hypertension |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Just after the end of the Stendo session.at D1 + 7 jours +/- 3 |