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The aim of this study is to evaluate the prevalence of metabolic syndrome, liver function abnormality and non-alcoholic fatty liver disease in early pregnancy patients, and the risk of pregnancy complications.
In cases in which metabolic syndrome and non-alcoholic fatty liver are risk factors of obstetric complications, such as gestational diabetes (GDM) or preeclampsia (PE), we are able to offer systematic clinical results from determining the independent risk factor and developing a predictable model. Recently, obstetric complications, especially GDM and PE, have increased due to the growth of elder pregnancy. In addition, as liver dysfunction has been known to be an independent risk factor of diabetes, cardiovascular disease, high blood pressure and renal dysfunction, its clinical importance has risen. Metabolic syndromes, such as obesity, hypertension, type II diabetes and abnormal lipid profile, have been known for its importance in development of non-alcoholic fatty liver disease. Considering abnormal liver function being an independent risk factor of diabetes, cardiovascular disease, high blood pressure and renal dysfunction in normal adult patients, we are able to predict that liver dysfunction might be a high risk factor of obstetric complications in pregnant women. In previous studies, the frequency of liver dysfunction in normal pregnant women was obtained.
The purpose of this current study was to investigate the prevalence of metabolic syndrome, abnormal liver function and non-alcoholic fatty liver in early pregnancy and the related risks of obstetric complications.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Liver ultrasound | Other | For evaluate whether fatty liver is exist or not |
| Measure | Description | Time Frame |
|---|---|---|
| Compare prevalence of obstetric complications between non-alcoholic fatty liver and normal pregnant women | Obstetrical complications include gestational diabetes, preeclampsia, etc Non-alcoholic fatty liver diagnosed by using liver ultrasound result of 1st trimester and blood test (AST, APT) | From date of enrollment until the date of delivery, assessed up to 35wks |
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Inclusion Criteria:
Exclusion Criteria:
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1st trimester pregnancy women with singleton
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| JEONGEUN Kwon, MD | Contact | 82-02-2072-3085 | ccoolicoola@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Joong Shin Park, MD PhD | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul Women's Hospital | Recruiting | Incheon | 402859 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38970008 | Derived | Zhang J, Suo Y, Wang L, Liu D, Jia Y, Fu Y, Fan W, Jiang Y. Association between atherogenic index of plasma and gestational diabetes mellitus: a prospective cohort study based on the Korean population. Cardiovasc Diabetol. 2024 Jul 5;23(1):237. doi: 10.1186/s12933-024-02341-9. | |
| 34649307 | Derived | Lee SM, Hwangbo S, Norwitz ER, Koo JN, Oh IH, Choi ES, Jung YM, Kim SM, Kim BJ, Kim SY, Kim GM, Kim W, Joo SK, Shin S, Park CW, Park T, Park JS. Nonalcoholic fatty liver disease and early prediction of gestational diabetes mellitus using machine learning methods. Clin Mol Hepatol. 2022 Jan;28(1):105-116. doi: 10.3350/cmh.2021.0174. Epub 2021 Oct 15. |
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| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D016640 | Diabetes, Gestational |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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serum for lab tests
| Seoul National University Hospital | Recruiting | Seoul | 110744 | South Korea |
|
| Seoul Metropolitan Goverment Seoul National University Boramae Medical Center | Recruiting | Seoul | 156707 | South Korea |
|
| D000091642 | Urogenital Diseases |
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |