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| Name | Class |
|---|---|
| Howard University | OTHER |
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Patients with type 1 diabetes type 1 (DM1) have increased risk of death due to heart disease and stroke. These cardiovascular conditions (CVD) are the leading cause of death in patients with DM1 younger than 40 years of age and up to 35% of all persons with DM1 will die before age 55 from CVD. Strategies are needed to help identify adolescents with DM1 at risk for CVD so that interventions to prevent heart disease and stroke can be undertaken.
Patients with type 1 diabetes and healthy controls will have evaluation of their lipid profile. Arterial stiffness, heart rate variability and adiposity measurements will be done in patients with type 1 diabetes and healthy controls. Blood pressure and heart rate will be recorded. 50 ml of urine will be collected from patients and controls.
All studies will be performed as a single outpatient visit at Georgetown University.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diabetes | Children with diabetes type 1 , 12-21 years old | ||
| Healthy | Healthy children 12-21 years old |
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| Measure | Description | Time Frame |
|---|---|---|
| small LDL particles | Blood test, based on NMR | This is an observational cross sectional study. Samples will be collected through study completion, on average of 6 years duration. |
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Inclusion Criteria:
Diabetes type 1 or Healthy
Exclusion Criteria:
Taking medications that lower cholesterol Duration of type 1 diabetes < 1 year.
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Children with diabetes type 1 and healthy children
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Evgenia Gourgari, MD | Contact | 2024441210 | ||
| Kathryn Turner | Contact | 2024442639 |
| Name | Affiliation | Role |
|---|---|---|
| Evgenia Gourgari | Georgetown University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Georgetown-Howard Universities Center | Recruiting | Washington D.C. | District of Columbia | 20007 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30922315 | Derived | Gourgari E, Ma J, Playford MP, Mehta NN, Goldman R, Remaley AT, Gordon SM. Proteomic alterations of HDL in youth with type 1 diabetes and their associations with glycemic control: a case-control study. Cardiovasc Diabetol. 2019 Mar 28;18(1):43. doi: 10.1186/s12933-019-0846-9. | |
| 30567548 | Derived | Gourgari E, Playford MP, Campia U, Dey AK, Cogen F, Gubb-Weiser S, Mete M, Desale S, Sampson M, Taylor A, Rother KI, Remaley AT, Mehta NN. Low cholesterol efflux capacity and abnormal lipoprotein particles in youth with type 1 diabetes: a case control study. Cardiovasc Diabetol. 2018 Dec 19;17(1):158. doi: 10.1186/s12933-018-0802-0. |
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| ID | Term |
|---|---|
| D003922 | Diabetes Mellitus, Type 1 |
| D048909 | Diabetes Complications |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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blood samples will be collected through study completion
| D004700 | Endocrine System Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |