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The purpose of this study is to validate the technique for the detection of left atrial fibrosis through segmentation of endocardial and epicardium landmarks of the images obtained with 3 Tgadobutrol-enhanced magnetic resonance with the software GIMIAS® in a cohort of healthy volunteers, without atrial fibrillation or known cardiovascular risk factors.
3D reconstructions obtained by GIMIAS® will be evaluated. Processing images will be carried out by two independent operators, and will calculate the kappa interobserver agreement .
Subsequently, the processed images are compared with images previously obtained in 10 patients with persistent atrial fibrillation adjusted for sex and age. A qualitative visual comparison will be made.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gadobutrol | Experimental | Gadobutrol in Healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gadobutrol | Drug | Gadobutrol administration in healthy volunteers |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of subjects with contrast enhancement in left atrium, measured through the reconstruction and processing of late enhancement magnetic resonance images with GIMIAS. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse events | 1 week after intervention | |
| Interobserver variability in the generation of segmented images of left atrium, measured through the kappa index. | 1 week after intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Clinic of Barcelona | Barcelona | Barcelona | 08036 | Spain |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| C090600 | gadobutrol |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |