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| ID | Type | Description | Link |
|---|---|---|---|
| 2014-A00511-46 | Other Identifier | ANSM |
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The main objective of this study is to show that "diaphragmatic excursion measures upon emergency admission" (CDA values) on patients with acute respiratory failure are predictive of the need to use mechanical ventilation (invasive or non-) in the first four hours.
The secondary objectives of this study are:
A-determine a prognostic threshold for diaphragmatic excursion measures able to predict the use of mechanical ventilation (invasive or not) in the first four hours.
B-to study the association between CDA values and persistence of respiratory distress during the first 4 hours of care among patients who, at 4 hours, are not mechanically ventilated.
C-to study the association between CDA values and respiratory re-exacerbation or a continuing need for mechanical ventilation during the 24 first hours after admission to the emergency room D-to study the association between diaphragmatic excursion measures made after initial emergency care (at 4 hours; =CDH4), and the persistence of respiratory distress at 4 hours, in patients who at 4 hours are not mechanically ventilated.
E-to study the association between CDH4 values and respiratory re-exacerbation during the 24 first hours after admission to the emergency room among patients who, at 4 hours, are not mechanically ventilated F-to study the association between changes in values of diaphragmatic excursion measure before and after initial emergency care (CDA → CDH4) and respiratory re-exacerbation during the 24 first hours after admission to the emergency room among patients who, at 4 hours, are not mechanically ventilated.
G-analyze patient outcomes by subgroup according to diagnosis (decompensated COPD, OAP, lung disease, asthma, pleural disease).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Prognostic study population | Experimental | The study population consists of patients treated for acute respiratory distress in the emergency department at the Nîmes University Hospital. See inclusion and exclusion criteria. Intervention: Diaphragmatic ultrasound |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vivid S6 GE Ultrasound | Device | Diaphragmatic ultrasound will be performed by the physician supporting the patient on arrival and also at 4 hours later in the beginning of therapeutic management. The patient will be monitored for 24 hours following inclusion. The exams will all be done with the same ultrasound system (Vivid S6 GE Ultrasound) and a phased array probe, also called a cardiac probe. |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of diaphragmatic excursion by M-mode ultrasound | in centimeters | Day 0, baseline |
| Use of ventilation within the first 4 hours | yes/no | Day 0, baseline + 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of diaphragmatic excursion by M-mode ultrasound | in centimeters | Day 0, baseline + 4 hours |
| Acute respiratory distress signs within the first 4 hours | yes/no |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Xavier Bobbia, MD | Centre Hospitalier Universitaire de Nīmes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU de Nîmes - Hôpital Universitaire Carémeau | Nîmes | 30029 | France | |||
| CH de Perpignan - Hôpital Saint Jean |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33142179 | Result | Clement A, Zieleskiewicz L, Bonnec JM, Occean BV, Bastide S, Muller L, de La Coussaye JE, Boussuges A, Claret PG, Bobbia X. Diaphragmatic excursion measurement in emergency department patients with acute dyspnea to predict mechanical ventilation use. Am J Emerg Med. 2020 Oct;38(10):2081-2087. doi: 10.1016/j.ajem.2020.06.044. Epub 2020 Jun 26. |
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| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| D004630 | Emergencies |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
| D020969 | Disease Attributes |
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|
| Day 0, baseline + 4 hours |
| Signs of respiratory re aggravation at 24 hours | yes/no | Day 1 |
| Diagnosis | qualitative variable: decompensated COPD, OAP, pneumonia, asthma, or pleural pathology | Day 1 |
| Perpignan |
| 66046 |
| France |
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |