Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.
Periodontitis is a polymicrobial inflammatory disease which includes various modifiable and nonmodifiable risk factors. The non modifiable risk factors include genetic polymorphisms like metabolism associated genetic polymorphisms ( Vitamin D and Calcitonin).
Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue with consequent increase in bone fragility and susceptibility to fractures.
Bone loss is a common feature shared between periodontal disease and osteoporosis.
Out of all genetic factors Calcitonin gene polymorphism contributes to the development of both osteoporosis and chronic periodontitis.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CTR Gene in Osteoporosis and Periodontitis | Patients aged between 35 - 60 yrs with Osteoporosis (BMD>-2.5) and Chronic Periodontitis (>3mm Pocket Probing Depth) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CTR Gene | Genetic | 2ml blood sample collected from patients to extract DNA for Assessment of CTR Gene polymorphism |
|
| Measure | Description | Time Frame |
|---|---|---|
| Calcitonin gene polymorphism | Collection of blood samples and running the samples by PCR | 5 Months |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Patients both male and female aged between 35-60 Years with Osteoporosis and Chronic Periodontitis.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Dr.Anuradha Ankam, PG(Perio) | Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre | Hyderabad | Andhra Pradesh | 500060 | India |
Not provided
| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| D055113 | Chronic Periodontitis |
| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
2ml of blood sample from each subject was collected in EDTA containing vials and kept at -20 degrees until DNA extraction. The genomic DNA was isolated and C/T polymorphism in CTR gene was identified by PCR followed by restriction digestion pattern by Alu 1 restriction enzyme.
| D009750 |
| Nutritional and Metabolic Diseases |
| D010518 | Periodontitis |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |