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| Name | Class |
|---|---|
| United States - Israel Binational Science Foundation | OTHER |
| Schneider Children's Hospital | OTHER |
| Sheba Medical Center | OTHER_GOV |
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First-line psychosocial treatments for anxiety disorders in children are largely exposure-based cognitive behavioral therapies (CBTs). Despite strong evidence supporting CBT's efficacy, for up to 50% of youth patients, symptoms of anxiety persist after a full course of treatment. What are the treatment options for these youth? Unfortunately, there is not a single empirical study in the youth anxiety treatment literature that has systematically examined treatment augmentation for youth who fail to respond to CBT. Empirical efforts to address this issue are important because youth who do not respond to CBT continue to suffer emotional distress and impairment associated with anxiety disorders. This study will address this gap via double-blind randomized controlled trial of Attention Bias Modification Treatment (ABMT) for anxious 10-18 year-olds who did not respond to standard CBT. Attention biases in threat processing have been assigned a prominent role in the etiology and maintenance of anxiety disorders. ABMT utilizes computer-based protocols to implicitly modify biased attentional patterns in anxious patients. Here, participants will be CBT non-responders who will be assessed by using clinical interviews and parent- and self-rated questionnaires before and after eight sessions of ABMT or placebo control, and again at an eight-week follow-up. We expect to see reduction in anxiety symptoms in the Attention Bias Modification Treatment (ABMT) group relative to the placebo control group. We also expect the findings to inform pathways to treatments for anxious children who do not respond to current standard first-line therapy, and to provide initial information on mechanisms of ABMT efficacy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Attention Bias Modification treatment (ABMT) | Experimental | Attention training via repeated trials of a dot-probe task intended to direct attention away from threat stimuli using threat and neutral stimuli. |
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| Placebo Group | Placebo Comparator | Attention training via repeated trials of a dot-probe task not intended to change threat-related attention patterns using only neutral stimuli. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Attention bias modification treatment (ABMT) | Behavioral | Attention training using a computerized spatial attention task (dot-probe) modified to alter threat-related attention patterns using threat and neutral stimuli. |
| Measure | Description | Time Frame |
|---|---|---|
| The Pediatric Anxiety Rating Scale (PARS) | The PARS assesses global anxiety severity across different anxiety disorders in youth. | expected average time frame of 6 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Anxiety Related Emotional Disorders - Child/Parent Version (SCARED-C/P) | The SCARED is a 41-item self and parent-report instrument designed to assess anxiety in children and adolescents. Screen for Child | expected average time frame of 6 weeks. |
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Inclusion Criteria:
To be included all youth must:
Exclusion Criteria: To be excluded youth must:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yair Bar-Haim, Prof. | Contact | 972-3-6405465 | yair1@post.tau.ac.il | |
| Marian Linetzky, M.A. | Contact | 972-54-4947028 | marian.linetzky@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tel-Aviv University | Recruiting | Tel Aviv | Israel |
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| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
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| Attention Control Condition | Behavioral | Attention training using a computerized spatial attention task (dot-probe) not intended to alter threat-related attention patterns using only neutral stimuli. |
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