Investigating the Role of the Polyol Pathway in the Central Nervous System

Investigating the Role of Polyol Pathway in the Central Nervous System

Patients will undergo magnetic resonance spectroscopy (MRS) scanning to noninvasively measure intracerebral and plasma metabolite levels at baseline and following 2 and 4 hours of hyperglycemia. Subjects will also undergo a lumbar puncture at a separate occasion to assess cerebrospinal fluid levels of metabolites.

Inclusion Criteria:

• Type 2 DM with HbA1C treated with metformin, sulfonylurea, insulin, or combination OR age-matched, non-diabetic obese (BMI > 30 kg/m^2) OR age-matched lean, healthy control subjects (BMI < 25 kg/m^2)
• Age 18-55
• BMI 18-45 kg/m^2

Exclusion Criteria:

• Creatinine > 1.5 mg/dL
• Hgb < 10 mg/dL
• ALT > 2.5 x ULN
• Untreated thyroid disease
• Uncontrolled Hypertension
• Known Neurological Disorders
• Untreated Psychiatric Disorders
• Malignancy
• Bleeding Disorders
• Smoking
• Current or recent steroid use in last 3 months
• Illicit drug use
• Pregnancy, actively seeking pregnancy, or breastfeeding
• Inability to enter MRI/MRS