Effect of a Butyrate Enema on the Systemic Concentration of Short Chain Fatty Acids

Effect of a Butyrate Enema on the Systemic Concentration of Short Chain Fatty Acids

In this placebo-controlled randomized parallel study the effects of a butyrate enema on plasma short-chain fatty acids (SCFA) concentrations and fluxes from portal drained viscera, liver and the splanchnic area are investigated

Patients undergoing upper abdominal surgery are included. During surgery they receive a butyrate enema or placebo enema. Before and after rectal administration, plasma samples are taken from several veins and arteries to analyse SCFA concentrations and fluxes from portal drained viscera, liver and the splanchnic area.

Inclusion Criteria:

• patients undergoing open liver resection or pancreaticoduodenectomy

Exclusion Criteria:

• known parenchymal liver disease
• presence of ileostomy or colostomy
• patients with inflammatory bowel disease
• antibiotics, prebiotics or probiotics 2 months prior to surgery