The Prevalence and Clinical Characteristics of Children With Local Allergic Rhinitis

The Prevalence and Clinical Characteristics of Children With Local Allergic Rhinitis

• To determine prevalence of local allergic rhinitis (LAR)
• To evaluate clinical characteristic and severity of local allergic rhinitis
• To measure changing of tryptase and Specific IgE for Dermatophagoides pteronyssinus (Dp) after nasal allergen provocation test (NAPT)

Children 8-18 years with NAR were recruited. A NAPT with Der p 1 solutions (NAPT-DP) at 200 AU/mL, 600 AU/mL and 2000 AU/mL at 15-minute interval was performed, respectively. The immediate responses to NAPT-DP were assessed using symptoms score, peak nasal inspiratory flow (PNIF) and acoustic rhinometry (ARM). The nasal tryptase and sIgE-DP were measured at baseline, 15 min and 1 h after positive NAPT-DP. Allergic rhinitis (AR) patients were used as positive control.

Inclusion Criteria:

• Children 8-15 years who were diagnosed with nonallergic rhinitis (NAR) at least 1 year
• No respiratory infections in the previous 4 weeks
• No following treatment of
• systemic corticosteroid 4 weeks
• intranasal corticosteroid 2 weeks
• oral antihistamine 1 week
• leukotriene antagonist 1 week

Exclusion Criteria:

• Patients with underlying disease:
• chronic rhinosinusitis and nasal polyp
• immunological disease
• chronic renal disease
• hepatobiliary disease
• cardiovascular disease
• cancer
• Parental withdraw consent
• Patient with uncontrolled asthma, peak expiratory flow rate (PEFR) < 80% of predicted