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Paroxysmal atrial fibrillation can only be diagnosed during episodes when the arrhythmia is present.
The investigators hypothesize that the activation of the atrial myocardium resulting in the p-wave of the ecg should display abnormalities in diseased atria which are vulnerable for AF.
In the first part of this trial different diagnostic techniques to detect arrythmogenic substrates of atrial fibrillation will be tested. If suitable parameters can be identified, a follow up trial to identify patients at risk for AF will be conducted before a stroke happens.
Parameters tested are
All patients will undergo a cardiogoniometrie and a pulse wave analysis with an iPhone. Each exam takes 5 minutes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Paroxysmal Af | No Intervention is planned. All patients receive a 5 Minute ECG and have their pulse recordes by an iPhone. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ECG | Device | Patients receive a 5 Minute ECG recording and have their pulse recorded by an iPhone. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Beat to beat variation of the electrical activation vector of the atrium | Test if the beat to beat Variation of the electrical activation of the atrium differentiates between the group of patients with paroxysmal AF and no AF in history. | Once during the exam (baseline) - No further follow up planned |
| Measure | Description | Time Frame |
|---|---|---|
| Averaged slope of pressure-curve | Test if the steepness of the slope of the pressure curve recorded with the iPhone differs between the two Groups. | Once during exam (5min, baseline) - No further follow up planned |
| Averaged slope of pressure-curve |
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Inclusion Criteria:
Exclusion Criteria:
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All inhospital and outpatient patients of our Institution with known paroxysmal AF are screened for eligebility. Control Group is equally recruted from patients of our intitution matching the studygroup.
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| Name | Affiliation | Role |
|---|---|---|
| Jens Eckstein, MD, PhD | Universityhospital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Basel | Basel | Canton of Basel-City | 4031 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30122130 | Derived | Brasier N, Engelter S, Kolbitsch T, Tabord A, Knobeloch J, Kuhne M, Conen D, Traenka C, Kreutzberger T, Vollmin G, Eckstein J. The quest for indicators of paroxysmal atrial fibrillation in sinus rhythm - the DETECT AF trial. Acta Cardiol. 2019 Aug;74(4):301-307. doi: 10.1080/00015385.2018.1493248. Epub 2018 Aug 19. |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| D020521 | Stroke |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D004562 | Electrocardiography |
| ID | Term |
|---|---|
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Test if the steepness of the slope of the pressure curve recorded with the iPhone correlates with cardiovascular risk factors.
| Once during exam (5min, baseline) - No further follow up planned |
| Heart rate variability | Test if heart rate variability recorded with the iPhone differs between the two Groups. | Once during exam (5min, baseline) - No further follow up planned |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D004568 | Electrodiagnosis |