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The purpose of the study is to evaluate the difference in learning and performance measures associated with repeated use of an iPad video game (Akili Interactive's Project: EVO) in healthy elderly volunteers based on amyloid status.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| (Amyloid Negative) |
| ||
| Amyloid Positive |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ritalin | Drug | 1 - 20 mg tablet taken once on Day 0 and taken once on Day 28 |
|
| Measure | Description | Time Frame |
|---|---|---|
| divided attention performance | The difference in effect of cognitive training on divided attention performance as measured by teh pre/post training change in interference cost on EVO dueal task assessment at Day 28. | Day 0 - Day 28 |
| Measure | Description | Time Frame |
|---|---|---|
| sustained attention, impulsivity and episodic memory | The difference in effect of cognitive training on sustained attention, impulsivity and episodic memory as measured by the pre/post training change in performance at day 28 | Day 0 - Day 28 |
| perforamce on EVO dual task assessment, TOVA and RAVLT |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pfizer CT.gov Call Center | Pfizer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Collaborative Neuroscience Network, LLC | Long Beach | California | 90806 | United States | ||
| Broward Research Group |
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| Label | URL |
|---|---|
| To obtain contact information for a study center near you, click here. | View source |
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| Placebo | Drug | 1 - matching tablet taken once on Day 0 and once on Day 28 |
|
|
| Ritalin | Drug | 1 - 20 mg tablet taken once on Day 0 and taken once on Day 28 |
|
|
| Placebo | Drug | 1 - matching tablet taken once on Day 0 and once on Day 28 |
|
|
The performance on EVO dual task assessment, Test of Variables of Attention (TOVA and Rey Auditory Verbal Learning Test (RAVLT) as measured by the pre and post training scores at Day 0 and Day 28 |
| Day 0 - Day 28 |
| within subject change on EVO, TOVA and RAVLT | The within subject change on EVO dual task assessment, TOVA and RAVLT between day -28 and Day 0. | Day 0 - Day 28 |
| Hollywood |
| Florida |
| 33024 |
| United States |
| Miami Research Associates | South Miami | Florida | 33143 | United States |
| Jasper Clinic, Inc. | Kalamazoo | Michigan | 49007 | United States |
| ID | Term |
|---|---|
| D008774 | Methylphenidate |
| ID | Term |
|---|---|
| D010648 | Phenylacetates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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