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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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This study compared the incretin-releasing effect of C8-diet oil and tributyrin with that of 20 ml olive oil on a molar basis in human volunteers.
A structured triglyceride (1,3-di-octanoyl-2-oleoyl-glycerol, called C8-diet oil), which upon digestion results in generation of two medium-chain fatty acids and 2-oleoyl-glycerol (2-OG), may lead to activation of GPR119 only, since medium fatty acids are poor agonists for fatty acid receptors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A meal containing carrot and tributyrin | Active Comparator | A meal containing 200 g grated carrot and 0.0216 mol tributyrin; blood test taken from 0 - 2 hours postprandial |
|
| A meal containing carrot and C8-diet oil | Active Comparator | A meal containing 200 g grated carrot and 0.0216 mol of C8-diet oil; blood test taken from 0 - 2 hours postprandial |
|
| A meal containing carrot and olive oil | Active Comparator | A meal containing 200 g grated carrot and 0.0216 mol of olive oil; blood test taken from 0 - 2 hours postprandial |
|
| A meal containing carrot | Placebo Comparator | A meal containing 200 g grated carrot; blood test taken from 0 - 2 hours postprandial |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tributyrin | Dietary Supplement | a triglyceride containing three C4-acids |
|
| Measure | Description | Time Frame |
|---|---|---|
| plasma GLP-1 | 2 hours postprandial | |
| plasma GIP | 2 hours postprandial |
| Measure | Description | Time Frame |
|---|---|---|
| plasma insulin | 2 hours postprandial | |
| plasma PYY | 2 hours postprandial | |
| plasma glucose |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jens J Holst, Professor | Biomedical Sciences, University of Copenhagen | Study Chair |
| Mette J Mandøe, Student | Glostrup Hospital; Biomedical Sciences, University of Copenhagen | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26178726 | Derived | Mandoe MJ, Hansen KB, Hartmann B, Rehfeld JF, Holst JJ, Hansen HS. The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans. Am J Clin Nutr. 2015 Sep;102(3):548-55. doi: 10.3945/ajcn.115.106799. Epub 2015 Jul 15. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| C005830 | tributyrin |
| D000069463 | Olive Oil |
| ID | Term |
|---|---|
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
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| C8-diet oil | Dietary Supplement | a triglyceride containing 2 C8-fatty acids and one oleic acid at sn-2 position |
|
| Olive oil | Dietary Supplement | a triglyceride containing mostly three oleic acids |
|
| Carrot | Dietary Supplement | mainly water and glucose |
|
| 2 hours postprandial |
| plasma neurotensin | 2 hour postprandial |
| plasma CCK | 2 hour postprandial |
| D004700 | Endocrine System Diseases |
| D005224 |
| Fats, Unsaturated |
| D010938 | Plant Oils |
| D009821 | Oils |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |