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| ID | Type | Description | Link |
|---|---|---|---|
| 5U19AT006057-02 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Center for Complementary and Integrative Health (NCCIH) | NIH |
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The overall goal of this project is to develop sensitive and objective clinical research tools for the assessment of head-neck motor control. In order to accomplish this goal, the investigators aim to quantify changes in head-neck motor control before and after osteopathic manipulative treatment. The investigators hypothesize that head-neck motor control will improve in neck pain participants after 4-weeks of treatment. Additionally, the investigators will compare position and force head-neck motor control between healthy controls and neck pain patients. The investigators hypothesize that baseline tests of position and force head-neck motor control will be better in healthy individuals than neck pain patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Immediate treatment | Experimental | This arm receives osteopathic manipulative treatment shortly after enrollment |
|
| Delayed treatment | Experimental | This arm receives osteopathic manipulative treatment approximately 4 weeks after enrollment |
|
| Healthy control (no neck pain) | No Intervention | In this arm, healthy controls are tested at baseline. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Osteopathic manipulative treatment | Procedure | Up to 4 sessions of osteopathic manipulative treatment (once per week) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline to week 4 and from week 4 to 8 in head position tracking accuracy | Participants will be seated in an upright position with their upper body secured to a backrest and will wear a head harness with an attached position sensor. The angular position of the head will be displayed on a monitor 1 meter in front of the participants and they will be asked to follow a moving target by moving their head. Accuracy will be determined by taking the difference between the target position signal and the actual head position (measured in degrees with string potentiometers). | Change from baseline to week 4 and from week 4 to 8 |
| Change from baseline to week 4 and from week 4 to 8 in head force tracking accuracy | Participants will be seated in an upright position with their upper body secured to a backrest and will be asked to generate force with their head against a fixed pad. The pad will be attached to a load cell that monitors how much force is being generated by their head. The force level will be displayed on a monitor 1 meter in front of the participants and they will be asked to follow a moving target by generating force with their head. Accuracy will be determined by taking the difference between target force signal and the actual head force (measured in Newtons with the load cell). | Change from baseline to week 4 and from week 4 to 8 |
| Change from baseline to week 4 and from week 4 to 8 in head position stabilization accuracy | Participants will be sitting upright in a seat mounted to a robotic platform (Mikrolar Hexapod Robot) with their upper body secured to a backrest and will wear a head harness with an attached position sensor. The robotic platform will provide an angular perturbation to the participant about the cervical spine in the sagittal plane while the participant is asked to maintain (stabilize) their head position in the upright posture. Accuracy will be determined by measuring the amount of head displacement (measured in degrees with string potentiometers) during the perturbation trial. | Change from baseline to week 4 and from week 4 to 8 |
| Change from baseline to week 4 in neck force and muscle activation directionality |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Patient Reported Outcomes Measurement Information System (PROMIS) | Assesses weekly changes in physical function, anxiety, depression, fatigue, sleep, satisfaction with social role, and pain with PROMIS-29 questionnaire. | The expected average is weekly for this outcome measure until the end (expected average of 8 weeks). |
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Inclusion Criteria:
All participants must meet all of the inclusion criteria to participate in the study. Below is a list of inclusion criteria for ALL participants:
Below is an additional list of inclusion criteria for NECK PAIN participants:
Exclusion Criteria:
All candidates meeting any of the exclusion criteria at baseline will be excluded from study participation. Exclusion criteria will be self-reported. However, during each treatment session, the physicians will be watching for clinical signs and symptoms not consistent with physical findings that are suggestive of the presence of any of the exclusion criteria. In such a case, further treatment will be discontinued and the subject will be excluded.
Below is a list of exclusion criteria for ALL participants:
History of:
Unresolved symptoms from:
Current diagnosis of:
Conditions recognized by a physician any time during the study:
Below is an additional exclusion criterion for healthy control participants:
• Based on the minimal clinically important difference of 2 points (Childs et al., 2005), "healthy controls" with 2 points or greater pain on NRS will not be eligible to participate.
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| Name | Affiliation | Role |
|---|---|---|
| Jacek Cholewicki, PhD | Michigan State University | Principal Investigator |
| Norman P Reeves, PhD | Michigan State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| MSU Osteopathic Manual Medicine | East Lansing | Michigan | 48823 | United States | ||
| MSU Musculoskeletal Rehabilitation |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24262851 | Background | Reeves NP, Popovich JM Jr, Priess MC, Cholewicki J, Choi J, Radcliffe CJ. Reliability of assessing trunk motor control using position and force tracking and stabilization tasks. J Biomech. 2014 Jan 3;47(1):44-9. doi: 10.1016/j.jbiomech.2013.10.018. Epub 2013 Oct 22. |
| Label | URL |
|---|---|
| Website for Michigan State University Center for Orthopedic Research | View source |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Mar 25, 2026 | |
| Reset | Apr 13, 2026 | |
| Release | Jun 10, 2026 | |
| Reset | Jul 7, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 25, 2026 | Apr 13, 2026 | |||
| Jun 10, 2026 |
| ID | Term |
|---|---|
| D019547 | Neck Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D026301 | Manipulation, Osteopathic |
| ID | Term |
|---|---|
| D026201 | Musculoskeletal Manipulations |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
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Participants will be seated in an upright position with their upper body secured to a backrest and will be asked to generate force with their head against a fixed pad. They will be asked to performed 6-seconds isometric exertions in different directions. Surface EMG will be recorded from the sternocliedomastoid, splenius capitis, and upper trapezius muscles. Muscle directionality will be determined by the EMG magnitude in each direction of exertion. |
| Change from baseline to week 4 |
| Change from week 4 to 8 in neck force and muscle activation directionality | Participants will be seated in an upright position with their upper body secured to a backrest and will be asked to generate force with their head against a fixed pad. They will be asked to performed 6-seconds isometric exertions in different directions. Surface EMG will be recorded from the sternocliedomastoid, splenius capitis, and upper trapezius muscles. Muscle directionality will be determined by the EMG magnitude in each direction of exertion. | Change from week 4 to 8 |
| Change in concomitant medication |
Assesses weekly changes in the use of medication for treating neck pain, including the type of medication and the quantity of medication (i.e., number of pills) with a questionnaire. |
| The expected average is weekly for this outcome measure until the end (expected average of 8 weeks). |
| Change in neck disability | Assesses weekly changes in functional activities related to neck disability with the Neck Disability Index questionnaire. | The expected average is weekly for this outcome measure until the end (expected average of 8 weeks). |
| Change in fear avoidance behavior | Assesses weekly changes in fear avoidance behavior using the Fear Avoidance Beliefs questionnaire. | The expected average is weekly for this outcome measure until the end (expected average of 8 weeks). |
| Lansing |
| Michigan |
| 48891 |
| United States |
| Michigan State University Center for Orthopedic Research | Lansing | Michigan | 48910 | United States |
| Website for the National Center for Complementary and Alternative Medicine (Sponsor) | View source |
| Jul 7, 2026 |
| D012046 | Rehabilitation |