Florida Neonatal Neurologic Network

Florida Neonatal Neurologic Network

Create a database with selected medical information on infants born with hypoxic-ischemic encephalopathy (HIE). In addition, the following samples will be collected in a bio-repository for future studies: blood, urine, and buccal samples.

The purpose of this study is to create a detailed medical and sample database of infants born with HIE. Both the medical information and the samples are de-identified. Any future studies performed with the data and samples will receive Institutional Review Board (IRB) approval.

Inclusion Criteria:

• Gestational Age greater than or equal to 35 weeks gestation
• Birth weight greater than or equal to 1.8 kg
• Less than or equal to 6 hours since insult occurred
• Severe hypoxic-ischemic encepholopathy (HIE)

Exclusion Criteria:

• Presence of lethal chromosomal abnormalities
• Severe IUGR
• Significant intracranial hemorrhage with a large intracranial hemorrhage (Grade III or intraparenchymal echodensity (Grade IV))