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The investigators are observing the effects 2,000 mg of L-tyrosine will have on 24 hour blood pressure fluctuations in individuals with Parkinson's disease.
We will be monitoring 24 hour ambulatory BP and HR in subjects with PD on 3 separate visits. The first visit will be without an intervention to establish a baseline of 24 hour BP fluctuations. One week later the subject will be given either L-tyrosine (2,000 mg) with B6 (10 mg) or a sugar pill. We will monitor 24 hour BP and HR after supplementation. One week later the subject will repeat the same procedures with either supplement or placebo.
This is a total of 3 visits with 24 hour ambulatory BP and HR monitoring.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| L-Tyrosine | Active Comparator | We will administer 1,000 mg of L-tyrosine BID for 24 hours and record BP and HR. |
|
| Sugar Pill | Placebo Comparator | We will administer a sugar pill BID for 24 hours and record BP and HR. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L-tyrosine | Dietary Supplement | Each subject will receive 2,000 mg of L-tyrosine BID for 24 hours. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood Pressure | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Heart Rate | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Joanne Donoghue, PhD | New York Institute of Technology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| New York Institute of Technology | Old Westbury | New York | 11758 | United States |
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| ID | Term |
|---|---|
| D014443 | Tyrosine |
| D000073893 | Sugars |
| ID | Term |
|---|---|
| D024322 | Amino Acids, Aromatic |
| D000598 | Amino Acids, Cyclic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
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| Sugar Pill | Dietary Supplement | Each subject will receive a sugar pill BID for 24 hours. |
|
| D002241 | Carbohydrates |