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| Name | Class |
|---|---|
| University of Stirling | OTHER |
| University of Birmingham | OTHER |
The ability to control our blood glucose (sugar) concentrations after a meal is a strong predictor of the risk of disease. Our bodies respond to glucose ingestion by reducing the amount of glucose from the liver entering the bloodstream. At the same time muscle increases the amount of glucose it take up from the bloodstream. This ensures that our blood glucose levels do not get too high. The investigators want to understand what happens to these processes following exercise after breakfast and after an overnight fast. In addition, the investigators also want to understand whether exercising with or without breakfast influences our appetite, food intake and activity levels later in the day.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Breakfast Rest | Active Comparator |
| |
| Breakfast Exercise | Active Comparator |
| |
| Fasted Exercise | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | Moderate intensity exercise |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Exogenous glucose appearance rate | Exogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes). | 120 minutes |
| Energy balance | Energy balance (intake minus expenditure) over 24 h from the beginning of the trial | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Endogenous glucose appearance rates | Endogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes). | 120 minutes |
| Glucose clearance rates | Glucose clearance rates following an oral glucose tolerance test (total clearance over 120 minutes). |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department for Health, University of Bath | Bath | BA2 7AY | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24986552 | Background | Gonzalez JT. Paradoxical second-meal phenomenon in the acute postexercise period. Nutrition. 2014 Sep;30(9):961-7. doi: 10.1016/j.nut.2013.12.001. Epub 2013 Dec 14. | |
| 23340006 | Background | Gonzalez JT, Veasey RC, Rumbold PL, Stevenson EJ. Breakfast and exercise contingently affect postprandial metabolism and energy balance in physically active males. Br J Nutr. 2013 Aug;110(4):721-32. doi: 10.1017/S0007114512005582. Epub 2013 Jan 29. |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D062408 | Breakfast |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Breakfast |
| Dietary Supplement |
Breakfast consumption |
|
| 120 minutes |
| Energy intake | Weighted energy intake over 24 hours from the beginning of the trial. | 24 h |
| Energy expenditure | Energy expenditure, derived from indirect calorimetry, acccelerometry and heart rate monitoring. | 24 h |
| Exogenous glucose appearance rates | Exogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes). | 120 minutes |
| 33512717 | Derived | Allaf M, Elghazaly H, Mohamed OG, Fareen MFK, Zaman S, Salmasi AM, Tsilidis K, Dehghan A. Intermittent fasting for the prevention of cardiovascular disease. Cochrane Database Syst Rev. 2021 Jan 29;1(1):CD013496. doi: 10.1002/14651858.CD013496.pub2. |
| 31321428 | Derived | Edinburgh RM, Hengist A, Smith HA, Travers RL, Betts JA, Thompson D, Walhin JP, Wallis GA, Hamilton DL, Stevenson EJ, Tipton KD, Gonzalez JT. Skipping Breakfast Before Exercise Creates a More Negative 24-hour Energy Balance: A Randomized Controlled Trial in Healthy Physically Active Young Men. J Nutr. 2019 Aug 1;149(8):1326-1334. doi: 10.1093/jn/nxz018. |
| D062407 | Meals |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |