Insufficient number of eligible and interested partients

The objective of this study is to apply Whole-body DW imaging alongside the routine management of patients requiring systemic therapy for metastatic breast cancer to compare the time to progression of individual liver metastases within and between patients following stable disease or partial response to palliative systemic therapy for breast cancer.

Inclusion Criteria:

• Age over 18 years.
• First metastatic breast cancer relapse after treatment for early stage disease
• A minimum of 10 evaluable lesions in the liver on routine x-ray CT imaging
• Patient prescribed cytotoxic, endocrine or biological therapies
• Patient physically and psychologically fit enough to consider sequential WB-- - DWI imaging alongside their standard disease monitoring
• Written informed consent

Exclusion Criteria:

• Diagnosis of other cancer within the last 5 years, other than resected non-melanoma skin cancer or cervical intraepithelial neoplasia
• Diagnosis of brain metastases.
• Contraindication to magnetic resonance MR imaging

Patients requiring systemic therapy for metastatic breast cancer