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| Name | Class |
|---|---|
| University of Malawi | OTHER |
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Randomized, double-blind, placebo controlled trial of a combined intervention of zinc, albendazole, and multiple micronutrients in improving environmental enteropathy in Malawian children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Multiple Intervention Arm | Experimental | single dose albendazole, two weeks of zinc, 24 weeks of multiple micronutrients |
|
| Placebo | Placebo Comparator | three placebos |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Albendazole | Drug |
| ||
| Zinc |
| Measure | Description | Time Frame |
|---|---|---|
| Dual Sugar Absorption Test | lactulose-mannitol ratio in urine | 12 weeks |
| Dual Sugar Absorption Test | lactulose-mannitol ratio in urine | 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Lactulose Excretion | percentage of ingested lactulose excreted in urine | 12 weeks |
| Lactulose Excretion | percentage of ingested lactulose excreted in urine |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mark J Manary, MD | Washington University in St. Louis; University of Malawi | Principal Investigator |
| Chrissie Thakwalakwa, PhD | University of Malawi | Study Director |
| Indi Trehan, MD MPH DTM&H | Washington University in St. Louis; University of Malawi | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Limela Rural Site | Limela | Machinga Distric | Malawi |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27807040 | Derived | Wang AZ, Shulman RJ, Crocker AH, Thakwalakwa C, Maleta KM, Devaraj S, Manary MJ, Trehan I. A Combined Intervention of Zinc, Multiple Micronutrients, and Albendazole Does Not Ameliorate Environmental Enteric Dysfunction or Stunting in Rural Malawian Children in a Double-Blind Randomized Controlled Trial. J Nutr. 2017 Jan;147(1):97-103. doi: 10.3945/jn.116.237735. Epub 2016 Nov 2. |
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| ID | Term |
|---|---|
| D015766 | Albendazole |
| D015032 | Zinc |
| ID | Term |
|---|---|
| D002219 | Carbamates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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|
| Multiple Micronutrient Supplement | Dietary Supplement |
|
| Placebo | Drug |
|
| 24 weeks |
| Mannitol Excretion | percentage of ingested mannitol excreted in urine | 12 weeks |
| Mannitol Excretion | percentage of ingested mannitol excreted in urine | 24 weeks |
| D001562 |
| Benzimidazoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D019216 | Metals, Heavy |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D028561 | Transition Elements |
| D008670 | Metals |