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The investigators want to evaluate the efficacy of the dexamethasone and paracetamol for the prevention of postoperative sore throat.
The postoperative sore throat is a common complication after the general anesthesia which decreases the quality of life. Dexamethasone is known to effective for the prevention of postoperative sore throat. The combined effect of the dexamethasone and paracetamol for postoperative sore throat, however, is not investigated.
The investigators want to evaluate the efficacy of the dexamethasone and paracetamol for the prevention of postoperative sore throat.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexamethasone | Active Comparator | Dexamethasone will be administered 30 minutes before the anesthetic induction. |
|
| Dexamethasone+ Paracetamol (DP) | Experimental | Dexamethasone will be administered 30 minutes before the anesthetic induction. Paracetamol will be administered at the end of the surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexamethasone | Drug | Dexamethasone will be administered. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative sore throat | Postoperative sore throat after 1 hour postoperatively will be measured (0:none, 1:mild, 2:moderate, 3:severe) | 1 hour postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative sore throat degree | Postoperative sore throat degree after 0, 1, 6, 24 hour postoperatively will be measured (11 points, 0:none, 10:worst imaginable). | 0, 1, 6, 24 hour postoperatively |
| Postoperative pain |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hyun-Chang Kim, MD | Contact | 82-10-2886-2876 | onidori1979@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Hee-Pyoung Park, PhD | Seoul National University of Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seolu National University of Hospital | Seoul | South Korea |
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| ID | Term |
|---|---|
| D010612 | Pharyngitis |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D003907 | Dexamethasone |
| D000082 | Acetaminophen |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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| Paracetamol | Drug | Paracetamol will be administered. |
|
Postoperative pain after 0, 1, 6, 24 hour postoperatively will be measured (11 points, 0:none, 10:worst imaginable).
| 0, 1, 6, 24 hour postoperatively |
| Nausea | Nausea will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6, 24 hour postoperatively |
| Vomiting | Vomiting will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6, 24 hour postoperatively |
| Somnolence | Somnolence will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6, 24 hour postoperatively |
| Shivering | Shivering will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6, 24 hour postoperatively |
| Headache | Headache will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6, 24 hour postoperatively |
| Hoarseness | Hoarseness will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6, 24 hour postoperatively |
| Dysphagia | Dysphagia will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6, 24 hour postoperatively |
| Analgesics | Analgesics usage will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6, 24 hour postoperatively |
| Postoperative sore throat | Postoperative sore throat after 0, 6, 24 hour postoperatively will be measured (0:none, 1:mild, 2:moderate, 3:severe) | 0, 6, 24 hour postoperatively |
| D012140 |
| Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |