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A single-center registry of patients with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack (TIA) who are emergently managed in the stroke care unit in the National Cerebral and Cardiovascular Center (NCVC) to determine change in underlying characteristics, stroke features and severity, process for diagnosis and acute treatment, and long-term outcomes of stroke/TIA patients over the years.
This is a single-center registry of consecutive patients with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack (TIA) who are emergently managed in the stroke care unit in the National Cerebral and Cardiovascular Center, a flagship stroke center in Japan.
Neurological emergencies other than stroke/TIA and subclinical cerebrobvascular inpatients are also enrolled.
Data are collected and analyzed to determine change in underlying characteristics, stroke features and severity, process for diagnosis and acute treatment, and long-term outcomes of stroke/TIA patients over the years.
The National Cerebral and Cardiovascular Center was founded in 1977 in Suita, Osaka, in order to provide the public with the most advanced treatment for cardiovascular and cerebrovascular diseases and to conduct the highest level of basic as well as applied research on the cardiovascular and cerebrovascular systems.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute ischemic stroke, acute ICH, TIA | Consecutive patients with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack who are emergently managed in the stroke care unit or stroke units in the National Cerebral and Cardiovascular Center |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | a single-center prospective observational study |
|
| Measure | Description | Time Frame |
|---|---|---|
| The modified Rankin Scale (mRS), a measure of disability | mRS scores range from 0 (no symptoms at all) to 6 (death) | 3 monhts |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants | Also assessing underlying patients' characteristics prior to index stroke/TIA | at entry |
| National Institutes of Health Stroke Scale score | Also assessing neurological and cognitive states |
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Inclusion Criteria:
Exclusion Criteria:
1) Patients considered by the investigator to be unsuitable for participating in this registry
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Inpatients
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| Name | Affiliation | Role |
|---|---|---|
| Kazunori Toyoda, MD, PhD | Vice Director of the Hospital, National Cerebral and Cardiovascular Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Cerebral and Cardiovascular Center | Suita | Osaka | 564-8565 | Japan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25030514 | Result | Toyoda K, Ninomiya T. Stroke and cerebrovascular diseases in patients with chronic kidney disease. Lancet Neurol. 2014 Aug;13(8):823-33. doi: 10.1016/S1474-4422(14)70026-2. | |
| 24200315 | Result | Osaki M, Miyashita F, Koga M, Fukuda M, Shigehatake Y, Nagatsuka K, Minematsu K, Toyoda K. Simple clinical predictors of stroke outcome based on National Institutes of Health Stroke scale score during 1-h recombinant tissue-type plasminogen activator infusion. Eur J Neurol. 2014 Mar;21(3):411-8. doi: 10.1111/ene.12294. Epub 2013 Nov 7. |
| Label | URL |
|---|---|
| Official home page of the National Cerebral and Cardiovascular Center | View source |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D000083242 | Ischemic Stroke |
| D002546 | Ischemic Attack, Transient |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| at entry |
| Volume of culprit infarcts/hematoma | ASPECTS on DWI for ischemia or hematoma volume using the ABC/2 method | at entry |
| The modified Rankin Scale (mRS), a measure of disability | mRS scores range from 0 (no symptoms at all) to 6 (death). Participants will be followed at hospital discharge, an expected average of 3 weeks. | around 3 weeks |
| The modified Rankin Scale (mRS), a measure of disability | mRS scores range from 0 (no symptoms at all) to 6 (death) | 1 year |
| Events of cardiovascular diseases including stroke/TIA | Participants will be followed at hospital discharge, an expected average of 3 weeks. | around 3 weeks |
| Events of cardiovascular diseases including stroke/TIA | 3 months |
| Events of cardiovascular diseases including stroke/TIA | 1 year |
| 24103668 | Result | Sakamoto Y, Sato S, Kuronuma Y, Nagatsuka K, Minematsu K, Toyoda K. Factors associated with proximal carotid axis occlusion in patients with acute stroke and atrial fibrillation. J Stroke Cerebrovasc Dis. 2014 May-Jun;23(5):799-804. doi: 10.1016/j.jstrokecerebrovasdis.2013.07.002. Epub 2013 Oct 6. |
| 23859180 | Result | Sato S, Uehara T, Hayakawa M, Nagatsuka K, Minematsu K, Toyoda K. Intra- and extracranial atherosclerotic disease in acute spontaneous intracerebral hemorrhage. J Neurol Sci. 2013 Sep 15;332(1-2):116-20. doi: 10.1016/j.jns.2013.06.031. Epub 2013 Jul 13. |
| 23652273 | Result | Kobayashi J, Uehara T, Toyoda K, Endo K, Ohara T, Fujinami J, Nagatsuka K, Minematsu K. Clinical significance of fluid-attenuated inversion recovery vascular hyperintensities in transient ischemic attack. Stroke. 2013 Jun;44(6):1635-40. doi: 10.1161/STROKEAHA.111.000787. Epub 2013 May 7. |
| 24621380 | Result | Tanaka K, Koga M, Sato K, Suzuki R, Minematsu K, Toyoda K. Three-dimensional analysis of the left atrial appendage for detecting paroxysmal atrial fibrillation in acute ischemic stroke. Int J Stroke. 2014 Dec;9(8):1045-51. doi: 10.1111/ijs.12268. Epub 2014 Mar 13. |
| 21960578 | Result | Tomii Y, Toyoda K, Suzuki R, Naganuma M, Fujinami J, Yokota C, Minematsu K. Effects of 24-hour blood pressure and heart rate recorded with ambulatory blood pressure monitoring on recovery from acute ischemic stroke. Stroke. 2011 Dec;42(12):3511-7. doi: 10.1161/STROKEAHA.111.628586. Epub 2011 Sep 29. |
| 24135558 | Result | Koga M, Arihiro S, Miyashita F, Yamamoto H, Yamada N, Nagatsuka K, Minematsu K, Toyoda K. Factors associated with early recanalization failure following intravenous rt-PA therapy for ischemic stroke. Cerebrovasc Dis. 2013;36(4):299-305. doi: 10.1159/000355054. Epub 2013 Oct 16. |
| 28361615 | Result | Inoue Y, Miyashita F, Koga M, Minematsu K, Toyoda K. Unclear-onset intracerebral hemorrhage: Clinical characteristics, hematoma features, and outcomes. Int J Stroke. 2017 Dec;12(9):961-968. doi: 10.1177/1747493017702664. Epub 2017 Mar 31. |
| 42379713 | Derived | Kuroda T, Tanaka T, Saito S, Bhaskar S, Ishiyama H, Inui R, Shiomi Y, Nakaoku Y, Ogata S, Morita Y, Ozaki E, Kuriyama N, Nishimura K, Koga M, Nakahara J, Toyoda K, Ihara M. Differential impact of smoking on intracerebral haemorrhage based on cerebral microbleed status: a case-control study. BMJ Open. 2026 Jun 30;16(6):e116158. doi: 10.1136/bmjopen-2025-116158. |
| 41585290 | Derived | Koge J, Tanaka K, Yoshimoto T, Shiozawa M, Ohta T, Satow T, Kataoka H, Ihara M, Koga M, Toyoda K. Mechanical Thrombectomy Beyond 2b Reperfusion: Should We Pursue a Higher Reperfusion Grade after Achievement of 2b? Stroke Vasc Interv Neurol. 2022 Jan 12;2(1):e000196. doi: 10.1161/SVIN.121.000196. eCollection 2022 Jan. |
| 41582976 | Derived | Yamaguchi E, Yoshimoto T, Ogura S, Saito K, Saito S, Hattori Y, Wasida K, Nishimura K, Toyoda K, Koga M, Ihara M. Association of the RNF213 p.R4810K Variant With the Outer Diameter of Cervical Arteries in Patients With Ischemic Stroke. Stroke Vasc Interv Neurol. 2022 Mar 24;2(6):e000298. doi: 10.1161/SVIN.121.000298. eCollection 2022 Nov. |
| 38187149 | Derived | Inui R, Koge J, Tanaka K, Yoshimoto T, Shiozawa M, Abe S, Ishiyama H, Imamura H, Nakahara J, Kataoka H, Ihara M, Toyoda K, Koga M. Detrimental effect of anemia after mechanical thrombectomy on functional outcome in patients with ischemic stroke. Front Neurol. 2023 Dec 19;14:1299891. doi: 10.3389/fneur.2023.1299891. eCollection 2023. |
| 37421278 | Derived | Yoshimoto T, Inoue M, Tanaka K, Koge J, Shiozawa M, Kamogawa N, Ishiyama H, Abe S, Imamura H, Kataoka H, Koga M, Ihara M, Toyoda K. Tmax Mismatch Ratio to Identify Intracranial Atherosclerotic Stenosis-Related Large-Vessel Occlusion Before Endovascular Therapy. J Am Heart Assoc. 2023 Jul 18;12(14):e029899. doi: 10.1161/JAHA.123.029899. Epub 2023 Jul 8. |
| 36708081 | Derived | Ikeda S, Saito S, Hosoki S, Tonomura S, Yamamoto Y, Ikenouchi H, Ishiyama H, Tanaka T, Hattori Y, Friedland RP, Carare RO, Kuriyama N, Yakushiji Y, Hara H, Koga M, Toyoda K, Nomura R, Takegami M, Nakano K, Ihara M. Harboring Cnm-expressing Streptococcus mutans in the oral cavity relates to both deep and lobar cerebral microbleeds. Eur J Neurol. 2023 Nov;30(11):3487-3496. doi: 10.1111/ene.15720. Epub 2023 Feb 16. |
| 36129032 | Derived | Okada T, Yoshimoto T, Wada S, Yoshimura S, Chiba T, Egashira S, Kimura S, Shiozawa M, Inoue M, Ihara M, Toyoda K, Takashima H, Koga M. Intravenous Thrombolysis With Alteplase at 0.6 mg/kg in Patients With Ischemic Stroke Taking Direct Oral Anticoagulants. J Am Heart Assoc. 2022 Oct 4;11(19):e025809. doi: 10.1161/JAHA.122.025809. Epub 2022 Sep 21. |
| 35400203 | Derived | Koge J, Tanaka K, Yoshimoto T, Shiozawa M, Kushi Y, Ohta T, Satow T, Kataoka H, Ihara M, Koga M, Isobe N, Toyoda K. Internal Carotid Artery Tortuosity: Impact on Mechanical Thrombectomy. Stroke. 2022 Aug;53(8):2458-2467. doi: 10.1161/STROKEAHA.121.037904. Epub 2022 Apr 11. |
| 34889115 | Derived | Inoue M, Yoshimoto T, Tanaka K, Koge J, Shiozawa M, Nishii T, Ohta Y, Fukuda T, Satow T, Kataoka H, Yamagami H, Ihara M, Koga M, Mlynash M, Albers GW, Toyoda K. Mechanical Thrombectomy Up to 24 Hours in Large Vessel Occlusions and Infarct Velocity Assessment. J Am Heart Assoc. 2021 Dec 21;10(24):e022880. doi: 10.1161/JAHA.121.022880. Epub 2021 Dec 10. |
| 34393139 | Derived | Yoshimoto T, Shiozawa M, Koge J, Inoue M, Koga M, Ihara M, Toyoda K. Evaluation of Workflow Delays in Stroke Reperfusion Therapy: A Comparison between the Year-Long Pre-COVID-19 Period and the with-COVID-19 Period. J Atheroscler Thromb. 2022 Jul 1;29(7):1095-1107. doi: 10.5551/jat.63090. Epub 2021 Aug 13. |
| 33594451 | Derived | Koge J, Tanaka K, Yoshimoto T, Shiozawa M, Yamagami H, Satow T, Takahashi JC, Ihara M, Koga M, Kira JI, Toyoda K. Early recurrent ischemic events after mechanical thrombectomy: effect of post-treatment intracranial hemorrhage. J Neurol. 2021 Aug;268(8):2810-2820. doi: 10.1007/s00415-021-10449-1. Epub 2021 Feb 16. |
| 31698986 | Derived | Yoshimoto T, Inoue M, Yamagami H, Fujita K, Tanaka K, Ando D, Sonoda K, Kamogawa N, Koga M, Ihara M, Toyoda K. Use of Diffusion-Weighted Imaging-Alberta Stroke Program Early Computed Tomography Score (DWI-ASPECTS) and Ischemic Core Volume to Determine the Malignant Profile in Acute Stroke. J Am Heart Assoc. 2019 Nov 19;8(22):e012558. doi: 10.1161/JAHA.119.012558. Epub 2019 Nov 8. |
| 31233392 | Derived | Fujita K, Tanaka K, Yamagami H, Ide T, Ishiyama H, Sonoda K, Satow T, Takahashi JC, Ihara M, Koga M, Yokota T, Toyoda K. Detrimental Effect of Chronic Hypertension on Leptomeningeal Collateral Flow in Acute Ischemic Stroke. Stroke. 2019 Jul;50(7):1751-1757. doi: 10.1161/STROKEAHA.119.025142. Epub 2019 May 16. |
| 28818863 | Derived | Takasugi J, Yamagami H, Noguchi T, Morita Y, Tanaka T, Okuno Y, Yasuda S, Toyoda K, Gon Y, Todo K, Sakaguchi M, Nagatsuka K. Detection of Left Ventricular Thrombus by Cardiac Magnetic Resonance in Embolic Stroke of Undetermined Source. Stroke. 2017 Sep;48(9):2434-2440. doi: 10.1161/STROKEAHA.117.018263. Epub 2017 Aug 17. |
| 27780903 | Derived | Hashimoto T, Hayakawa M, Funatsu N, Yamagami H, Satow T, Takahashi JC, Nagatsuka K, Ishibashi-Ueda H, Kira JI, Toyoda K. Histopathologic Analysis of Retrieved Thrombi Associated With Successful Reperfusion After Acute Stroke Thrombectomy. Stroke. 2016 Dec;47(12):3035-3037. doi: 10.1161/STROKEAHA.116.015228. Epub 2016 Oct 25. |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D002545 | Brain Ischemia |